Kajian Pustaka Sintesis Nanopartikel Tembaga Menggunakan Ekstrak Tanaman sebagai Bioreduktor dan Aplikasinya sebagai Antibakteri

Rita Sugiyarti, Hilda Aprilia Wisnuwardhani, Bertha Rusdi

Abstract


Abstract: Copper nanoparticles (CuNP) are one of the metal nanoparticles, besides gold and silver, which are widely used in the pharmaceutical field. Copper nanoparticles are widely applied, especially in relation to their antibacterial and antioxidant acivities, as and other applications in the pharmaceutical. The search results show plant that can be used as bioreductors are plants that contain flavonoid compounds such as Persea americana, Zingiber officinale, Punica granatum, Falcaria vulgaris, Cissus vitiginea. As well as plants that contain phenols such as plant Ziziphus spina-christi, Agaricus bisporus, and Curcuma longa. The copper nanoparticles synthesized using plant extract formed have spherical in shape and an average size of 20-100 nm. SPR formed is in the range of 350-631 nm. Copper nanoparticles showed high antibacterial effectiveness against Gram-negative bacteria (Pseudomonas aeroginosa, Escherichia coli, Klebsiella pneumoniae, Salmonella thypii) and Gram-positive bacteria (Propionabacterium acnes, Streptococcus sp, Staphylococcus aureus, Bacillus aureus, Enterococcus sp) with an inhibition zone between 20-28 mm. So that these copper nanoparticles can be used as one of the antibacterial candidates.

Keywords: Bioreductor, Green synthesis, copper nanoparticles, antimicrobial.

Abstrak: Nanopartikel tembaga (CuNP) merupakan salah satu nanopartikel logam, selain emas dan perak yang banyak dimanfaatkan di dunia Farmasi. Nanopartikel tembaga banyak diaplikasikan terutama kaitannya dengan aktivitasnya sebagai antibakteri dan antioksidan, juga beberapa aplikasi lainnya di dunia Farmasi. Penelitian ini bertujuan untuk mengetahui tanaman yang dapat digunakan sebagai bioreduktor, karakteristik, dan aplikasi CuNP sebagai antibakteri. Hasil penelusuran pustaka menunjukan bahwa tanaman yang dapat digunakan sebagai bioreduktor yaitu tanaman yang memiliki kandungan senyawa flavonoid seperti pada tanaman Persea americana, Zingiber officinale, Punica granatum, Falcaria vulgaris, Cissus vitiginea. Serta tanaman yang memiliki kandungan fenol seperti pada tanaman Ziziphus spina-christi, Agaricus bisporus, dan Curcuma longa. Nanopartikel tembaga yang di sintesis menggunakan ekstrak tanaman tersebut rata-rata memiliki bentuk yang bulat dan ukurannya 20-100 nm. Serta SPR yang terbentuk yaitu berkisar 350-631 nm. Nanopartikel tembaga menunjukan efektivitas antibakteri yang tinggi terhadap bakteri Gram negatif (Pseudomonas aeroginosa, Escherichia coli, Klebsiella pneumoniae, Salmonella thypii) dan bakteri Gram positif (Propionabacterium acnes, Streptococcus sp, Staphylococcus aureus, Bacillus aureus, Enterococcus sp) dengan zona hambat antara 20-28 mm. Sehingga nanopartikel tembaga ini dapat digunakan untuk salah satu kandidat antibakteri.

Kata kunci: Bioreduktor, sintesis hijau, nanopartikel tembaga, antimikroba


Keywords


Bioreduktor, sintesis hijau, nanopartikel tembaga, antimikroba

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DOI: http://dx.doi.org/10.29313/.v0i0.31035

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