Kajian Pustaka Aktivitas Antihipertensi Beberapa Ekstrak Tanaman dari Suku Malvaceae terhadap Penurunan Tekanan Darah
Abstract
ABSTRACT: High blood pressure is a degenerative disease characterized by an increase in blood pressure in the body. The purpose of this study was to see the potential of several plant extracts that have been studied as antihypertensives, the effective dose of the extracts as antihypertensives and to determine the secondary metabolite compounds that play a role in antihypertensives. Based on the results obtained from the literature review, several plants from the Family Malvaceae, namely Rosella (Hibiscus sabdariffa L.), Okra (Abelmoschus esculentus), and Baobab (Adansonia digitata) have potential activity as antihypertensives, also produce effective doses to reduce blood pressure and some of these plants also contain secondary metabolites including flavonoids and alkaloids that have a role in antihypertensives.
Keyword: Antihypertensive, Hypertensive, Extract, In vivo
ABSTRAK: Tekanan darah tinggi (hipertensi) merupakan salah satu penyakit degeneratif yang ditandai dengan adanya peningkatan suatu tekanan darah di dalam tubuh.. Tujuan penilitian ini adalah untuk melihat potensi beberapa ekstrak tanaman yang telah diteliti sebagai antihipertensi, dosis efektif pada ekstrak sebagai antihipertensi dan mengetahui senyawa metabolit sekunder yang berperan dalam antihipertensi. Berdasarkan hasil yang telah didapatkan dari kajian pustaka bahwa beberapa tanaman yang berasal dari suku malvaceae secara yaitu Rosella (Hibiscus sabdariffa L.), Okra (Abelmoschus esculentus), dan Baobab (Adansonia digitata) memiliki potensi aktivitas sebagai antihipertensi, juga menghasilkan dosis efektif untuk menurunkan tekanan darah dan beberapa tanaman tersebut juga mengandung senyawa metabolit sekunder diantaranya flavonoid dan alkaloid yang berperan dalam antihipertensi
Kata Kunci: Antihipertensi, Hipertensi, Ekstrak, In vivo
Keywords
Full Text:
PDFReferences
Adib, M. (2009). Cara Mudah Memahami Dan Menghindar Hipertensi, Jantung, Dan Stroke, Dianloka, Yogyakarta.
Balogun, M. E., Besong, E. E., Obimma, J. N., Iyare, E. E., & Nwachukwu, D. C. (2019). Ameliorative effect of aqueous extract of Hibiscus sabdariffa (roselle) on salt-induced hypertension in Wistar rats. Pharmacologyonline, 2, 247-258.
Balogun, M. E., Nwachukwu, D. C., Iyare, E. E., Besong, E. E., Obimma, J. N., & Djobissie, S. F. (2016). Antihypertensive effect of methanolic extract from the leaves of Hibiscus Sabdariffa L. in rats. Der Pharm Lett, 8(19), 473-84.
Chauhan, J.S., Cahturvedi, R., Kumar, S., (1984). A new flavonol glycoside from the root of A. digitata. Planta Medica 50, 113.
Chauhan, J.S., Kumar, S., Cahturvedi, R. (1987). A new flavonone glycoside from the root of A. Digitata, National Academy of Science Letters 10, 177–179.
Da-Costa-Rocha, I, Bonnlaender, B, Sievers, H, PischelI & Heinrich, M. (2014). Hibiscus sabdariffa L., A phytochemical and pharma-cological review, Food Chemistry, 165:424-443.
Fauza, A., Djamiatun, K., & Al-Baarri, A. N. M. (2019). Studi Karakteristik dan Uji Aktivitas Antioksidan dari Tepung Buah Okra (Abelmoschus esculentus). Jurnal Aplikasi Teknologi Pangan, 8(4), 137-142.
Golt, L N and Yang S N. (2019). Treatment of Hypertension: A Review Yangtze Medicine: 3, 101-123.
Ignatavicius, Workman, & Rebar. (2017). Medical Surgical Nursing: Concepts For Interprofessional Collaborative Care (9 th ed.). St. Louis : Elsevier, Inc.
Kumar, D.S., D.E. Tony, A.P. kumar, K.A. Kumar, D.B. S. Rao, R. Nadendia. (2013). A Review on: Abelmoschus esculentus (okra). Int. Res J Pharm. App Sci., 3(4):129- 132
Mahadevan, N, Shivali, P & Kamboj. (2009). Hibiscus sabdariffa Linn., An overview. Natural Product Radiance. 8(1):77–83.
Malkoff, J. (2011). Non-invasive Blood Pressure for Mice and Rats, Kent Scientific Corporation, Animal Lab News
Mardiah et al. (2009). Budi Daya dan Pengolahan Rosela Si Merah Segudang Manfaat. PT. Agromedia Pustaka, Jakarta.
Mondal, K., KP, S. G., & Manandhar, S. (2019). Anti-hypertensive Effect of Abelmoschus Esculentus (Okra) Seed Extracts in Fructose-induced Hypertensive Rats. Indian J Physiol Pharmacol, 63(2), 175-181.
Ntchapda, F., Bonabe, C., Atsamo, A. D., Kemeta Azambou, D. R., Bekono Fouda, Y., Imar Djibrine, S., ... & Théophile, D. (2020). Effect of Aqueous Extract of Adansonia digitata Stem Bark on the Development of Hypertension in L-NAME-Induced Hypertensive Rat Model. Evidence-Based Complementary and Alternative Medicine.
Oktaviani, T., & Megantara, S. (2018). Aktivitas Farmakologi Ekstrak Rosella (Hibiscus sabdariffa L.). Farmaka, 16(1).
Olivera, DF, Mugridge, AC, Haves, AR, Mascheroni, RH,Onyenekwe PC, Ajani EO, Ameh DA, Gamaniel KS (1999). Efek antihipertensi infus kelopak bunga rosella (Hibiscus sabdariffa) pada tikus hipertensi spontan dan perbandingan toksisitasnya dengan tikus Wistar. Biokimia Sel. Fungsi 17(3): 199-206. Owolabi OA,
Sherwood, L. (2007.) Human Physiology From Cells to Systems. 7th edition. Canada : Brooks/Cole Cengange learning. p. 229, 231.
Sheu, S.C., Lai, M.H. (2012). Composition analysis and immuno-modulatory effect of Okra (Abelmoschus esculentus L.) extract. Food Chemical 134(4):1906–1911.
Shukla, Y.N., Dubey, S., Jain, S.P., Kumar, S. (2001). Chemistry, biology and uses of Adansonia digitata a review. Journal of Medicinal and Aromatic Plant Sciences 23, 429–434
Tavafi M. (2016). Hibiscus esculentus against hyperglycemia and dyslipidemia. Ann Res Antioxid. vol. 1, no. 2, pp. 4–5.
Abdurrozak Mohammad Ihsan, Syafnir Livia, Sadiyah Esti Rachmawati. (2021). Uji Efektivitas Ekstrak Etanol Daun Angsana (Pterocarpus Indicus Willd) sebagai Biolarvasida terhadap Larva Nyamuk Culex Sp. Jurnal Riset Farmasi, 1(1), 33-37.
DOI: http://dx.doi.org/10.29313/.v0i0.30528
