Kajian Jenis Bahan Penstabil dan Metode Pembuatan pada Pengembangan Sediaan Nanosuspensi untuk Penghantaran Agen Sitotoksik

Retno Asri Hanayuki, Sani Ega Priani, Sri Peni Fitrianingsih

Abstract


ABSTRACT: Cancer is a disease that originates from the body's tissue cells which is characterized by rapid cell division. One form of nanoparticle delivery that is widely used for cancer treatment with the aim of increasing the bioavailability of higher drugs is nanosuspension. The success of the development of nanosuspension preparations is influenced by two things, namely the type of stabilizer and the method of manufacture. This study aims to determine the effect of the type of stabilizer and the method of manufacture in the development of nanosuspension preparations on the activity of cytotoxic agents. This research was conducted using a Systematic Literature Review (SLR) based on inclusion and exclusion criteria. The results of the study found 11 active compounds that have been developed into nanosuspension preparations including deacety mycoepoxydiene, celastrol, annonaceous acetogenins, curcumin, oridonin, hydroxy-genkwanin, genkwanin, ceramide and docetaxel, dilsufiram, and PIK-75. Stabilizers that can be used for the development of nanosuspension preparations are polymers or surfactants, namely lecithin, poloxamer-188, HPMC, PVP, sodium deoxycholate (SDC), TPGs (D-α-Tocopheryl polyethylene glycol succinate 1000), and hydroxypropyl-beta- cyclodextrin (HP-β-CD), where this type of stabilizer is able to stabilize nanosuspension by steric, electrostatic, and electrosteric stabilization and nanosuspension preparations can be developed using top-down or bottom-up methods.

Keywords: Systematic Literature Review (SLR), nanosuspension, cancer

ABSTRAK: Kanker merupakan penyakit yang berasal dari sel-sel jaringan tubuh yang ditandai dengan pembelahan sel yang cepat. Salah satu bentuk penghantaran nanopartikel yang banyak digunakan untuk pengobatan kanker dengan tujuan untuk meningkatkan bioavaibilitas obat yang lebih tinggi adalah nanosuspensi. Keberhasilan pengembangan sediaan nanosuspensi dipengaruhi oleh dua hal yaitu jenis bahan penstabil dan metode pembuatannya. Kajian ini bertujuan untuk mengetahui pengaruh jenis bahan penstabil dan metode pembuatan dalam pengembangan sediaan nanosuspensi terhadap aktivitas agen sitotoksik. Penelitian ini dilakukan secara Systematic Literature Review (SLR) dengan berdasarkan kriteria inklusi dan eksklusi. Hasil kajian mendapatkan 11 senyawa aktif yang telah dikembangkan menjadi sediaan nanosuspensi diantaranya adalah deacety mycoepoxydiene, celastrol, annonaceous acetogenins, curcumin, oridonin, hidroksi-genkwanin, genkwanin, ceramide dan docetaxel, dilsufiram, dan PIK-75. Bahan penstabil yang dapat digunakan untuk pengembangan sediaan nanosuspensi yaitu seperti golongan polimer atau surfaktan yaitu lesitin, poloksamer-188, HPMC, PVP, sodium deoxycholate (SDC), TPGs (D-α-Tocopheryl polyethylene glycol succinate 1000), dan hidroksipropil-beta-siklodekstrin (HP-β-CD), dimana jenis bahan penstabil tersebut mampu menstabilkan nanosuspensi secara stabilisasi sterik, elektrostatik, dan elektrosterik serta sediaan nanosuspensi dapat dikembangkan dengan menggunakan metode top-down atau bottom-up.

Kata Kunci: Systematic Literature Review (SLR), nanosuspensi, cancer


Keywords


Systematic Literature Review (SLR), nanosuspensi, cancer

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References


Aher, S. S., Malsane, S. T. and Saudagar, R. B. (2017) ‘NANOSUSPENSION : AN OVERVIEW’, International Journal of Current Pharmaceutical Research, 9(3), pp. 19–23.

Ahire, E. et al. (2018) ‘Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications’, Acta Pharmaceutica Sinica B, 8(5), pp. 733–755.

Ao, H. et al. (2020) ‘Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer’, Drug Delivery, 27(1), pp. 816–824.

Bi, M. and XQ Miao MS, SF Chow PhD, WJ Wu MS, R Yan PhD, Y. (2016) ‘Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution’.

Bilgili, E., Li, M. and Afolabi, A. (2016) ‘Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?’, Pharmaceutical Development and Technology, 21(4), pp. 499–510.

Feng, F. F. et al. (2011) ‘Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension’, Drug Delivery, 18(4), pp. 265–271.

Freag, M. S., Elnaggar, Y. S. R. and Abdallah, O. Y. (2013) ‘Development of novel polymer-stabilized diosmin nanosuspensions: In vitro appraisal and ex vivo permeation’, International Journal of Pharmaceutics, 454(1), pp. 462–471.

Gao, L., Zhang, D. and Chen, M. (2008) ‘Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system’, Journal of Nanoparticle Research, 10(5), pp. 845–862.

Gao, Y. et al. (2011) ‘Preparation and characterization of intravenously injectable curcumin nanosuspension’, 18(July 2010), pp. 131–142.

Hering, I. et al. (2020) ‘Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants’, Environmental Toxicology and Pharmacology, p. 103353.

Hong, J. et al. (2016) ‘Colloids and Surfaces B : Biointerfaces Annonaceous acetogenins ( ACGs ) nanosuspensions based on a self-assembly stabilizer and the significantly improved anti-tumor efficacy’, Colloids and Surfaces B: Biointerfaces, 145, pp. 319–327..

Huang, T. et al. (2020) ‘Preparation of high drug-

loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo’, Scientific Reports, 10(1), pp. 1–9.

Ibrahim, M. A., Elosaily, G. M. and Shazly, G. (2018) ‘Formulation and Evaluation of Docetaxel Nanosuspensions : In-vitro Evaluation and Cytotoxicity Formulation and Evaluation of Docetaxel Nanosuspensions ’:, Saudi Pharmaceutical Journal.

Jacob, S., Nair, A. B. and Shah, J. (2020) ‘Emerging role of nanosuspensions in drug delivery systems’, pp. 1–16.

Kathe, N., Henriksen, B. and Chauhan, H. (2014) ‘Physicochemical characterization techniques for solid lipid nanoparticles: Principles and limitations’, Drug Development and Industrial Pharmacy, 40(12), pp. 1565–1575.

Li, H. et al. (2020) ‘Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug ‑ loading content : remarkably improved antitumor efficacy’, Journal of Nanobiotechnology, pp. 1–11.

Li, Y. et al. (2017) ‘Genkwanin nanosuspensions : a novel and potential antitumor drug in breast carcinoma therapy’, Drug Delivery, 0(0), pp. 1491–1500.

Liu, G. et al. (2013) ‘In vitro and in vivo evaluation of riccardin D nanosuspensions with different particle size’, Colloids and Surfaces B: Biointerfaces, 102, pp. 620–626.

Mahesh, K. V., Singh, S. K. and Gulati, M. (2014) ‘A comparative study of top-down and bottom-up approaches for the preparation of nanosuspensions of glipizide’, Powder Technology, 256, pp. 436–449.

Oktay, A. N. et al. (2020) ‘Journal of Drug Delivery Science and Technology Screening of stabilizing agents to optimize fl urbiprofen nanosuspensions using experimental design’, Journal of Drug Delivery Science and Technology, 57(February), p. 101690.

Patel, V. R. and Agrawal, Y. K. (2011) ‘Nanosuspension : An approach to enhance solubility of drugs’, 2(2), pp. 81–88.

Prastiwi, T. F. (2012) ‘Kualitas Hidup penderita Kanker’, Developmental and Clinical Psychology, 1(1), pp. 21–27.

Purkayastha, H. Das and Hossian, S. K. I. (2019) ‘Nanosuspension: a Modern Technology Used in Drug Delivery System’, International Journal of Current Pharmaceutical Research, 11(3), pp. 1–3.

Reningtyas, R. and Mahreni (2015) ‘Biosurfaktan’, Eksergi, XII(2), pp. 12–22.

Sajeev Kumar, B. et al. (2014) ‘Development and characterization of lecithin stabilized glibenclamide nanocrystals for enhanced solubility and drug delivery’, Drug Delivery, 21(3), pp. 173–184..

Talekar, M. et al. (2013) ‘Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy’, International Journal of Pharmaceutics, 450(1–2), pp. 278–289.

Wang, L., Tian, S. and Wang, Y. (2015) ‘Nanosuspensions of poorly water soluble drugs prepared by bottom-up technologies’, Elsevier B.V.

Wang, T. et al. (2017) ‘Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency’, Drug Delivery, 24(1), pp. 800–810.

Wang, Y. et al. (2011) ‘Colloids and Surfaces B : Biointerfaces Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension Me’, Colloids and Surfaces B: Biointerfaces, 83(2), pp. 189–197.

Wang, Y., Ma, Y., et al. (2013) ‘In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer , with high efficacy and low toxicity’, 441, pp. 728–735.

Wang, Y., Zhang, L., et al. (2013) ‘Stability issue of nanosuspensions in drug delivery’, Journal of Controlled Release.

World Health Organization (2020) ‘International Agency for Research on Cancer’, 256, pp. 1–2.

Zhou, Y. et al. (2018) ‘Comparative studies on amphotericin B nanosuspensions prepared by a high pressure homogenization method and an antisolvent precipitation method’, Colloids and Surfaces B: Biointerfaces.

Azhar Salma Fadhilah, Y Kiki Mulkiya, Kodir Reza Abdul. (2021). Pengaruh Waktu Aging dan Metode Ekstraksi terhadap Aktivitas Antioksidan Black Garlic yang Dibandingkan dengan Bawang Putih (Allium sativum L.). Jurnal Riset Farmasi, 1(1), 16-23.




DOI: http://dx.doi.org/10.29313/.v0i0.30501

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