Studi Literatur Senyawa Steroidal Saponin dari Genus Dracaena
Abstract
ABSTRACT: The Genus dracaena are known by a variety of uses of each tradition can be used as a treatment and ornamental plants in the room for an air purifier, have a secondary metabolite compounds. Dracaena is known to be rich in compounds of steroidal saponins which have pharmacological activity. This literature study aims to find out the compounds of steroidal saponins that exist in some the genus dracaena and to know the differences of the structure of the compounds of each genus dracaena which affect the physicochemical properties and activities. This literature study using a research journal that performs insulation, collected about 8 of the genus dracaena which have compounds of steroidal saponins. The results of this research, there are compounds of steroidal saponins with different structures, as well as having pharmacological activity including anti-inflammatory, antiproliferative and cytotoxic properties have
Keywords: Dracaena, steroidal saponin, pharmacological activity
ABSTRAK: Genus dracaena dikenal dengan berbagai kegunaan disetiap tradisi dapat digunakan sebagai pengobatan dan tanaman hias dalam ruangan untuk pembersih udara, memiliki senyawa metabolit sekunder. Dracaena ini dikenal kaya akan senyawa steroidal saponin yang memiliki aktivitas farmakologi. Studi literatur ini bertujuan untuk mengetahui senyawa steroidal saponin yang ada pada beberapa genus dracaena dan untuk mengetahui perbedaan dari struktur senyawa dari setiap genus dracaena yang mempengaruhi sifat fisikokimia maupun aktivitasnya. Studi literatur ini menggunakan jurnal penelitian yang melakukan isolasi, terkumpul sekitar 8 genus dracaena yang memiliki senyawa steroidal saponin. Hasil dari penelitian ini terdapat senyawa steroidal saponin dengan struktur yang berbeda, serta memiliki aktivitas farmakologi termasuk antiinflamasi, antiproliferatif dan memiliki sifat sitotoksik.
Kata kunci: Dracaena, steroidal saponin, aktivitas farmakologi
Keywords
Full Text:
PDFReferences
Giraud, M. F., & Naismith, J. H. (2000). The rhamnose pathway. Current Opinion in Structural Biology, 10(6), 687–696. https://doi.org/10.1016/S0959-440X(00)00145-7
González, A. G., Hernández, J. C., León, F., Padrón, J. I., Estévez, F., Quintana, J., & Bermejo, J. (2003). Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities. Journal of Natural Products, 66(6), 793–798. https://doi.org/10.1021/np020517j
Guclu-Ustundag, Ö., & Mazza, G. (2007). Saponins: Properties, applications and processing. Critical Reviews in Food Science and Nutrition, 47(3), 231–258. https://doi.org/10.1080/10408390600698197
Huang, H. C., Lin, M. K., Hwang, S. Y., Hwang, T. L., Kuio, Y. H., Chang, C. I., Ou, C. Y., & Kuo, Y. H. (2013). Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb. Molecules, 18(8), 8752–8763. https://doi.org/10.3390/molecules18088752
Kougan, G. B., Miyamoto, T., Tanaka, C., Paululat, T., Mirjolet, J. F., Duchamp, O., Sondengam, B. L., & Lacaille-Dubois, M. A. (2010). Steroidal saponins from two species of dracaena. Journal of Natural Products, 73(7), 1266–1270. https://doi.org/10.1021/np100153m
Lu, P. (2012). Systematics, Evolution, and Biogeography among Dracaenoid Genera: Dracaena, Pleomele, and Sansevieria (Asparagaceae). Dissertation.
Mimaki, Y., Kuroda, M., Takaashi, Y., & Sashida, Y. (1997). Concinnasteoside A, a new bisdesmosidic cholestane glycoside from the stems of Dracaena concinna. Journal of Natural Products, 60(11), 1203–1206. https://doi.org/10.1021/np9703095
Mimaki, Yoshihiro, Kuroda, M., Ide, A., Kameyama, A., Yokosuka, A., & Sashida, Y. (1999). Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells. Phytochemistry, 50(5), 805–813. https://doi.org/10.1016/S0031-9422(98)00614-1
Moharram, F. A., & El-Shenawy, S. M. (2007). Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet. Planta Medica, 73(10), 1101–1106. https://doi.org/10.1055/s-2007-981565
Rezgui, A., Mitaine-Offer, A. C., Pertuit, D., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P., & Lacaille-Dubois, M. A. (2013). Steroidal saponins from Dracaena marginata. Natural Product Communications, 8(2), 157–160. https://doi.org/10.1177/1934578x1300800205
Tang, L., Wang, Z., Wu, H., Yokosuka, A., & Mimaki, Y. (2014). Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity. Phytochemistry, 107, 102–110. https://doi.org/10.1016/j.phytochem.2014.07.021
Tapondjou, L. A., Ponou, K. B., Teponno, R. B., Mbiantcha, M., Djoukeng, J. D., Nguelefack, T. B., Watcho, P., Cadenas, A. G., & Park, H. J. (2008). In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii. Archives of Pharmacal Research, 31(5), 653–658. https://doi.org/10.1007/s12272-001-1208-3
Thu, Z. M., Oo, S. M., Nwe, T. M., Aung, H. T., Armijos, C., Hussain, F. H. S., & Vidari, G. (2021). Structures and bioactivities of steroidal saponins isolated from the genera dracaena and sansevieria. In Molecules (Vol. 26, Issue 7). https://doi.org/10.3390/molecules26071916
Xu, M., Zhang, Y. J., Li, X. C., Jacob, M. R., & Yang, C. R. (2010). Steroidal saponins from fresh stems of Dracaena angustifolia. Journal of Natural Products, 73(9), 1524–1528. https://doi.org/10.1021/np100351p
Zhang, Y., Li, H. Z., Zhang, Y. J., Jacob, M. R., Khan, S. I., Li, X. C., & Yang, C. R. (2006). Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea. Steroids, 71(8), 712–719.https://doi.org/10.1016/j.steroids.2006.04.005
Zhu, Z. X., Mu, W. X., Wang, J. H., Zhang, J. R., Zhao, K. K., Ross Friedman, C., & Wang, H. F. (2018). Complete plastome sequence of Dracaena cambodiana (Asparagaceae): a species considered “Vulnerable†in Southeast Asia. Mitochondrial DNA Part B: Resources, 3(2), 620–621. https://doi.org/10.1080/23802359.2018.1473740.
R Fathan Said, Darma Gita Cahya Eka, Kodir Reza Abdul. (2021). Formulasi sediaan Cuka Buah Kopi Menggunakan Ragi (Saccharomyces cerevisiae) dan Bakteri (Acetobacter aceti). jurnal Riset Farmasi, 1(1), 38-45.
DOI: http://dx.doi.org/10.29313/.v0i0.29926
