Studi Literatur Aktivitas Antihiperglikemik Beberapa Tanaman dari Famili Rosaceae Secara In Vivo

Iska Savitri, Ratu Choesrina, Siti Hazar

Abstract


ABSTRACT: Diabetes mellitus is a disease in which glucose levels in the blood increase due to the body's inability to use or release insulin sufficiently. Plants from the Rosaceae family are known to have the potential as antihyperglycemics because these plants are known to contain a class of flavonoid compounds that can increase insulin sensitivity. The purpose of this literature study is to find out how the antihyperglycemic activity of several plants from the Rosaceae family and to know whats group of compounds are contained in these plants. The method used in this research is in the form of a systematic literature review. In this study, it was found that plant extracts from the Rosaceae family had an antihyperglycemic activity with several effective doses. These plants include Pyrus spp., Prunus cerasus, Potentilla chinensis, Malus toringoides, Fragaria ananassa, Fragaria nilgerrensis, Amelanchier alnifolia, and Rubus rosifolius. The antihyperglycemic activity of the extract is known to be due to the content of secondary metabolites, namely flavonoids, triterpenes, phenolic acids, ferulic acid, vanillic acid, phenylpropanoids, anthocyanins, fatty acids, and triacylglycerol (TAG).

Keywords: Diabetics, Antihyperglychemics, Rosaceae, In vivo

ABSTRAK: Penyakit diabetes melitus adalah suatu penyakit dimana kadar glukosa yang terdapat didalam darah meningkat yang disebabkan oleh ketidakmampuan tubuh untuk menggunakan atau melepaskan insulin secara cukup. Tanaman yang berasal dari famili Rosaceae diketahui memiliki potensi sebagai antihiperglikemik karena pada tanaman tersebut diketahui mengandung golongan senyawa flavonoid yang dapat meningkatkan sensitivitas insulin. Tujuan dari studi literatur ini adalah untuk mengetahui bagaimana aktivitas antihiperglikemik beberapa tanaman dari famili Rosaceae dan mengetahui golongan senyawa apa saja yang terkandung pada tanaman tersebut. Metode yang digunakan pada penelitian ini yaitu berupa studi literatur yang dilakukan secara sistematis. Pada penelitian ini diketahui bahwa ekstrak tanaman dari famili Rosaceae memiliki aktivitas antihiperglikemik dengan beberapa dosis efektif. Tanaman tersebut antara lain Pyrus spp., Prunus cerasus, Potentilla chinensis, Malus toringoides, Fragaria ananassa, Fragaria nilgerrensis, Amelanchier alnifolia, dan Rubus rosifolius. Aktivitas antihiperglikemik pada ekstrak diketahui karena adanya kandungan senyawa metabolit sekunder yaitu flavonoid, triterpen, asam fenolat, asam ferulat, asam vanilat, fenilpropanoid, antosianin, asam lemak, dan triasilgliserol (TAG).

Kata Kunci: Diabetes, Antihiperglikemik, Rosaceae, In Vivo


Keywords


Diabetes, Antihiperglikemik, Rosaceae, In Vivo

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DOI: http://dx.doi.org/10.29313/.v0i0.29829

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