Kajian Literatur Sintesis dan Karakterisasi Nanopartikel Emas Menggunakan Ekstrak Tanaman sebagai Bioreduktor dan Aktivitas Antibakterinya

Devina Ummul Agniya Ravana, Anggi Arumsari, Hilda Aprilia Wisnuwardhani

Abstract


ABSTRACT: In recent years, the application of gold nanoparticles has been studied in various fields. Therefore, a synthesis method has to be developed becoming effective and environmentally friendly synthesis methods. So, gold nanoparticles synthesis research using bioreductors from various plant extracts. In this literature study, several studies will be observed based on various plant extracts as natural bioreductors and their effect on the characteristics of the gold nanoparticles formed. In addition, the antibacterial activity of the resulting gold nanoparticles and the factors influencing were also studied. From this study, it was found that the use of various plant extracts as bioreductors resulted in different characteristics of gold nanoparticles and antibacterial activity, this is influenced by bioreductor, extraction and synthetic methods, volume composition of extracts and precursors, concentration of nanoparticles, temperature, shape and size of nanoparticles also the type of tested bacteria. It was also known that the most optimal antibacterial activity was produced using Glycyrrhzia glabra L extract as bioreductor because it produced the largest inhibition zone

Keywords: Plant Bioreductor, AuNPs, Characterization, Antibacterial

ABSTRAK: Dalam beberapa tahun terakhir, aplikasi nanopartikel emas telah banyak dipelajari diberbagai bidang. Oleh karena itu mulai dikembangkan metode sintesis yang tidak hanya efektif tapi sekaligus ramah lingkungan. Akhir-akhir ini sudah mulai banyak dilakukan penelitian sintesis nanopartikel emas menggunakan bioreduktor dari berbagai ekstrak tanaman. Pada studi literatur ini akan dipelajari beberapa penelitian mengenai penggunaan berbagai ekstrak tanaman sebagai bioreduktor alami dan pengaruhnya terhadap karakteristik nanopartikel emas yang terbentuk. Selain itu dipelajari juga aktivitas antibakteri dari nanopartikel emas yang dihasilkan dan faktor-faktor yang mempengaruhinya. Dari beberapa penelitian tersebut, diperoleh hasil bahwa penggunaan berbagai ekstrak tanaman sebagai bioreduktor menghasilkan karakteristik nanopartikel emas dan aktivitas antibakteri yang berbeda-beda, hal ini dipengaruhi oleh faktor bioreduktor, metode ekstraksi dan sintetis, komposisi volume ekstrak dan prekursor, konsentrasi nanopartikel, suhu, bentuk dan ukuran nanopartikel serta jenis bakteri yang diujikan. Pada studi literatur ini juga diketahui bahwa aktivitas antibakteri paling optimal dihasilkan pada penggunaan bioreduktor ekstrak Glycyrrhzia glabra L karena dihasilkan zona hambat paling besar

Kata kunci: bioreduktor tanaman, AuNPs, karakterisasi, antibakteri


Keywords


bioreduktor tanaman, AuNPs, karakterisasi, antibakteri

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References


Aljabali, A. A. A., Akkam, Y., Al Zoubi, M. S.., Al Batayneh, K. M., Al Trad, B. A., Alrob., O. A., Alkilany, A. M., Benamara, M., Evans, D. J. (2018). Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity. Nanomaterials. No. 8, hal 174.

Aprilia, T. S. 2018. Preparasi dan Karakterisasi Nanopartikel Emas EkstrakDaun Singkong Karet (Manihot glazovii) dengan Proses Biosintesis HighEnergy.

Babayi, H., Kolo, I., Okogun, J.I., Ijah, and U.J.J. (2004). The antimicrobial Activities of Methanolic Extract of Eucalyptus camaldulensis and Terminalia catappa Againt some Pathogenic Microorganisms. An Int. J. Niger. Soc. Exp. Bio., No. 16, Vol 2, hal 106-111.

Balalakshmi, C., Gopinan, K., Govindarajan, M., Lokesh, R., Arumugam, A., Kadaikunna, S., Khaled, JM., Benelli, G. 2017. Green Synthesis of Gold Nanoparticles using a Cheap Sphaeranthus indicus Extract: Impact on Plant Cells and The Aquatic Crustacean Artemia nauplii. Journal of Photochemistry & Photobiology, B: Biology. S1011-1344(17)30731-5.

Balasubramanian, S., Kala, S. M. J., Pushparaj, T. L., Kumar, P. V. (2019). Biofabrication of Gold Nanoparticles Using Cressa cretica Leaf Extract and Evaluation of Catalytic and Antibacterial Efficacy. Nano Biomed, Vol. 11, Iss. 1.

Boomi, P., Poorani, G. P., Selvam, S., Palanisamy, S., Jegatheeswaran, S., Anand K., Balakumar, C., Premkumar, K., Prabu, H., G. (2019). Green biosynthesis of gold nanoparticles using Croton sparsiflorus leaves extract and evaluation of UV protection, antibacterial and anticancer applications. John Wiley & Sons, Ltd.

Das, R. K., Bhuyan, D. (2019). Microwave mediated green synthesis of gold and silver nanoparticles from fruit peel aqueous extract of Solanum melongena L. and study of antimicrobial property of silver nanoparticles. Nanotechnology for Environmental Engineering. No. 4, Vol. 5.

Dhas, T. S., Sowmiya, P., Kumar, V. G., Ravi, M., Suthindhiran, K., Borgio, J. F., Narendrakumar, G., Kumar, V. R., Karthick, V., Kumar, C. M. V. (2020). Antimicrobial effect of Sargassum plagiophyllum mediated gold nanoparticles on Escherichia coli and Salmonella typhi. Biocatalysis and Agricultural Biotechnology. No. 26.

El Borady, O. M., Ayat, M. S., Shabrawy, M. A., Miller, P. (2020). Green synthesis of gold nanoparticles using Parsley leaves extract and their applications as an alternative catalytic, antioxidant, anticancer, and antibacterial agents. Advanced Powder Technology.

Fatimah, I., Hidayat, H., Nugroho, B. I., Husein, S. (2020). Ultrasound-assisted biosynthesis of silver and gold nanoparticles using Clitoria ternatea flower. South African Journal of Chemical Engineering. No. 34, hal 97-106.

Fazrin, E. I., Naviardianti, A. I., Wyantuti, S., Gaffar, S., Hartati, Y. W. (2020). Review: Sintesis Dan Karakterisasi Nanopartikel Emas (AuNP) Serta Konjugasi AuNP Dengan DNA Dalam Aplikasi Biosensor Elektrokimia, Jotnal of Science Education, Universitas Pandjajaran, Sumedang, Vol. 4, No. 2, hal. 21-39.

Ghalehsoukhteh, S. L., Jalaei, J., Fazeli, M., Memarian, P., Shekarforoush, S. (2018). Evaluation of ‘green’ synthesis and biological activity of gold nanoparticles using Tragopogon dubius leaf extract as an antibacterial agent. IET Nanobiotechnol. Vol. 12, hal 1118-1124.

Hafid, S., Zakir, M., Dali, S. (2015). Pemanfaatan Fraksi Etil Asetat Daun Ketapang (Terminalia Catappa) Sebagai Bioreduktor Dalam Sintesis Nanopartikel Emas dan Analisi Sifat Abtibakterinya. Jurusan Kimia, FMIPA, Universitas Hasanuddin, Makasar.

Hamelian, M., Hemmati, S., Varmira, K., Veisi, H. (2018). Green synthesis, antibacterial, antioxidant and cytotoxic effect of gold nanoparticles using Pistacia Atlantica extract. Journal of the Taiwan Institute of Chemical Engineers. No. 14, Vol. 18.

Ismail, S. K., Khan, M. A., Haque, A., Ghosh, S., Roy, D., Homechuandhuri, S., Alam, M. A. (2020). Synthesis of gold and silver nanoparticles using Malva verticillata leaves extract: Study of gold nanoparticles catalysed reduction of nitro-Schiff bases and antibacterial activities of silver nanoparticles. Current Research in Green and Sustainable Chemistry. No. 3.

Khan, S. A., Shadid, S., Lee, C. S. (2020). Green Synthesis of Gold and Silver Nanoparticles Using Leaf Extract of Clerodendrum inerme; Characterization, Antimicrobial, and Antioxidant Activities. Biomolecules. Vol 10, hal 835.

Keshavamurthy, M., Srinath, B. S., Rai, V. R. (2017). Phytochemicals Mediated Green Synthesis of Gold Nanoparticles Using Pterocarpus Santalinus L. (Red Sanders) Bark Extract and Their Antimicrobial Properties. Particulate Science and Technology. No. 23, Vol. 15.

Muniyappan, N., Pandeeswaran, M., Amalraj, A. (2021). Green synthesis of gold nanoparticles using Curcuma pseudomontana isolated curcumin: Its characterization, antimicrobial, antioxidant and anti- inflammatory activities. Environmental Chemistry and Ecotoxicology. No. 3, hal 117-124.

Moustafa, N. E., Alomari., A. A. (2019). Green synthesis and bactericidal activities of isotropic and anisotropic spherical gold nanoparticles produced using Peganum harmala L leaf and seed extracts. Biotechnology and Applied Biochemistry.

Nagalingam, M., Kalpana, V. N., Rajeswari, D., Panneerselvam, A. (2018). Biosynthesis, characterization, and evaluation of bioactivities of leaf extract-mediated biocompatible gold nanoparticles from Alternanthera bettzickiana. Biotechnology Reports. No. 19.

Radadi, N. (2021). Facile one-step green synthesis of gold nanoparticles (AuNp) using licorice root extract: Antimicrobial and anticancer study against HepG2 cell line. Arabian Journall Chemistry. No. 14.

Rahmawati, N. H., Islam, A. I., Kurniawati, R. (2020). Smart Biosensor Berbasis Emas-Nanopartikel Sebagai Teknologi Mutakhir Deteksi Penyakit Triple Burden Disase. Journal of the Indonesia Scientific Society (JISS), Vol. I, No. 1.

Valsalaman, S., Agastian, P., Esmail. G. A., Ghilan, A. K. M., Al Dhabi, N. A., Arasu, M. V. (2019). Biosynthesis of silver and gold nanoparticles using Musa acuminata colla flower and its pharmaceutical activity against bacteria and anticancer efficacy. Photochemistry and Photobiology.

Veena, S., Devasana, T., Sathak, S. S. M., Yasasve, M., Vishal, L. A. (2019). Green Synthesis of Gold Nanoparticles from Vitex negundo Leaf Extract: Characterization and In Vitro Evaluation of Antioxidant– Antibacterial Activity. Journal of Cluster Science.

Vijayan, R., Joseph, S., Mathew, B. (2018). Anticancer, antimicrobial, antioxidant, and catalytic activities of green-synthesized silver and gold nanoparticles using Bauhinia purpurea leaf extract. Bioprocess and Biosystems Engineering. No. 42, hal 305-319.

Zhou, Y., Y. Kong, S. Kundu, et al. (2012). Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus CalmetteGuérin. J Nanobiotechnology, 10: 19.

Nuraeni Anisa Dwi, Lukmayani Yani, Kodir Reza Abdul. (2021). Uji Aktivitas Antibakteri Propionibacterium acnes Ekstrak Etanol dan Fraksi Daun Karuk (Piper sarmetosum Roxb. Ex. Hunter) serta Analisis KLT Bioautografi. Jurnal Riset Farmasi, 1(1), 9-15.




DOI: http://dx.doi.org/10.29313/.v0i0.29388

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