Pengaruh Penggunaan Beberapa Polimer terhadap Pelepasan Obat pada Floating Tablet dalam Pengobatan Penyakit Lambung
Abstract
ABSTRACT: The FDDS (Floating Drug Delivery System) system is designed to increase availability by extending the time of the drug in the stomach. The purpose of this study was to determine the formulation of floating tablets, to determine the effect of several polymers used on drugs and to determine the effectiveness of floating tablets for the treatment of diseases compared to conventional drugs. The method used in this study is a systematic literature review which is done by searching for secondary literature data that has been published from articles that have been indexed by SINTA and SCOPUS. The results showed that the floating tablet formulation can be made using two systems, namely effervescent and non-effervescent systems; showed that the tablet was affected by the viscosity and concentration of the polymer used, from each polymer combination, the drug time was found to be in the range of 6-24 hours; ofloxacin and cefuroxime are antibiotics that can treat Helicobacter pylori that causes gastric disease, in floating form producing better Cmax and Tmax values than the conventional form.
Keywords: Drug release, Floating tablets, Effervescent System Polymers, Non-effervescent Polymers, Helicobacter pylori.
ABSTRAK: Sistem FDDS (Floating Drug Delivery System) dibuat untuk meningkatkan ketersediaan hayati dengan cara memperlambat pelepasan obat dan memperpanjang waktu tinggal obat di lambung. Tujuan dari penelitian ini adalah untuk mengetahui formulasi pada floating tablet, mengetahui pengaruh dari beberapa polimer yang digunakan terhadap pelepasan obat serta mengetahui efektivitas floating tablet untuk pengobatan penyakit lambung dibandingkan terhadap obat konvensional. Metode yang digunakan pada penelitian ini adalah systematic literature review dilakukan dengan mencari literature data sekunder yang telah dipublikasi dari artikel yang telah terindeks SINTA dan SCOPUS. Hasil penelitian menunjukan bahwa formulasi floating tablet dapat dibuat dengan menggunakan dua sistem, yaitu sistem effervescent dan non-effervescent; pelepasan tablet dipengaruhi oleh viskositas dan konsentrasi polimer yang digunakan, dari masing-masing kombinasi polimer, didapatkan waktu pelepasan obat ada dalam rentang 6-24 jam; ofloxacin dan cefuroxime merupakan antibiotik yang dapat mengobati Helicobacter pylori yang menyebabkan penyakit lambung, dalam bentuk floating menghasilkan nilai Cmax dan Tmax yang lebih baik dibandingkan bentuk konvensional.
Kata Kunci: Pelepasan obat, Floating tablet, Polimer Sistem effervescent, Polimer Non-effervescent, Helicobacter pylori.
Keywords
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DOI: http://dx.doi.org/10.29313/.v0i0.28929
