Kajian Pengaruh Sistem Nanoemulsi terhadap Penghantaran Transdermal Senyawa Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Abstract
ABSTRACT: Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs used to reduce pain and inflammation. To optimize drug delivery, many NSAIDs have been developed into nanoemulsion preparations, especially for drugs that have low solubility in water. This study aims to determine the effect of developing a nanoemulsion system on percutaneous penetration and the analgesic or anti-inflammatory activity of NSAIDs. This research is in the form of a systematic literature review by identifying, analyzing, evaluating, and interpreting all the findings into articles. The study was conducted on articles from reputable databases that met the inclusion and exclusion criteria. From the results of the literature study, it is known that the development of nanoemulsion preparations for transdermal delivery of NSAID compounds such as aceclofenac, etoricoxib, ibuprofen, indomethacin, lornoxicam, and diclofenac sodium led to an increase in percutaneous penetration which was characterized by an increase in the percentage of drug penetration or flux values with the percentage increase varying from 28,57-1355,85%. Increased penetration further affects the increase in anti-inflammatory or analgesic activity which is characterized by an increase in the percentage of edema inhibition and a decrease in nociceptive score.
Keywords: NSAIDs compound, Nanoemulsion, Penetration, Transdermal.
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ABSTRAK Obat NSAIDs (Non Steroidal Anti-inflammatory Drugs) merupakan obat yang digunakan untuk mengurangi rasa nyeri dan peradangan. Untuk optimalisasi penghantarannya obat NSAIDs banyak dikembangkan menjadi sediaan nanoemulsi, terutama untuk obat yang memiliki kelarutan rendah dalam air. Penelitian ini bertujuan untuk mengetahui pengaruh pengembangan sistem nanoemulsi terhadap penetrasi perkutan dan aktivitas analgesik atau antiinflamasi senyawa NSAIDs. Penelitian ini dalam bentuk Systematic Literature Review dengan mengidentifikasi, menganalisis, mengevaluasi, serta meninterpretasikan seluruh hasil temuan ke dalam artikel. Kajian dilakukan terhadap artikel dari database bereputasi yang memenuhi kriteria inklusi dan eksklusi. Dari hasil studi literature diketahui bahwa pengembangan sediaan nanoemulsi untuk penghantaran transdermal senyawa NSAIDs seperti aceclofenac, etoricoxib, ibuprofen, indometasin, lornoxicam, dan natrium diklofenak menyebabkan peningkatkan penetrasi perkutan yang ditandai dengan peningkatan persen penetrasi obat atau nilai fluks dengan persen peningkatkan bervariasi dari 28,57-1355,85%. Peningkatan penetrasi selanjutnya berpengaruh terhadap peningkatan aktivitas antiinflamasi atau analgesik yang ditandai dengan peningkatan persen penghambatan edema dan penurunan skor nosiseptif.
Kata Kunci: Senyawa NSAIDs, Nanoemulsi, Penetrasi, Transdermal.
Keywords
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DOI: http://dx.doi.org/10.29313/.v0i0.28693
