Studi Literatur Beberapa Ekstrak Tanaman yang Memiliki Aktivitas Imunostimulan
Abstract
Abstract: Infectious disease is one disease category with a high prevalence nowadays. Some plants are having potential to stimulate the immune system against pathogens that cause the diseases. Extracts of Echinacea purpurea, Morinda citrifolia, Phyllanthus niruri, Andrographis paniculata and Centella asiatica have potential as immunostimulant agents. This literature study aims to find out the activity of Echinacea purpurea, Morinda citrifolia, Andrographis paniculata, Phyllanthus niruri and Centella asiatica plants as immunostimulants and its mechanism in stimulating the immune system to prevent and against infectious diseases. This literature study was conducted on twelve articles from national dan international journals, three journalr are national journals and nine journals are international journals. Four studies provided measurement cytokine levels, three studies provided measurement immune cell proliferation, two studies provided measurement antibody elevation, one study measured the phagocytosis index and another measured the ∆G value. In addition, the test method and concentration of the extract were also explained. Result from this study showed that administration of extracts of Echinacea purpurea, Morinda citrifolia, Andrographis paniculata, Phyllanthus niruri and Centella asiatica increased cytokine secretion, T lymphocyte proliferation, antibodies, macrophage activity in phagocytosis and elimination of cells infected by pathogens.
Keywords:Â Immunostimulant, immune system, Echinacea purpurea, Morinda citrifolia, Andrographis paniculata, Phyllanthus niruri, Centella asiatica.
Abstrak: Penyakit infeksi merupakan salah satu penyakit dengan prevalensi yang tinggi pada masa sekarang ini. Beberapa tanaman memiliki potensi untuk menstimulasi sistem imun dalam melawan pathogen penyebab penyakit. Ekstrak Echinacea purpurea, Morinda citrifolia, Phyllanthus niruri, Andrographis paniculata dan Centella asiatica berpotensi sebagai agen imunostimulan. Studi literatur ini bertujuan untuk mengetahui aktivitas tanaman Echinacea purpurea, Morinda citrifolia, Andrographis paniculata, Phyllanthus niruri dan Centella asiatica sebagai imunostimulan dan mekanismenya dalam menstimulasi sistem imun untuk mencegah dan melawan penyakit infeksi. Studi literatur dilakukan dari tiga jurnal nasional dan sembilan jurnal internasional. Empat penelitian mengukur kadar sitokin, tiga penelitian mengukur prloliferasi sel imun, dua penelitian mengukur peningkatan antibodi, satu penelitian mengukur indeks fagositosis dan satu penelitian lain mengukur nilai ∆G. Selain itu dijelaskan juga metode uji dan konsentrasi ekstrak. Hasil dari studi ini menunjukan esktrak Echinacea purpurea, Morinda citrifolia, Andrographis paniculata, Phyllanthus niruri dan Centella asiatica meningkatkan sekresi sitoki, proliferasi limfosit T, antibodi, aktivitas makrofag dalam memfagositosis dan pengeliminasian sel yang terinfeksi oleh patogen.
Kata kunci:Â Imunostimulan, sistem imun, Echinacea purpurea, Morinda citrifolia, Andrographis paniculata, Phyllanthus niruri, Centella asiatica.
Keywords
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A, A. (2018). Cellular and molecular immunology 9th Edition. California: Saunders Elsevier.
Achiro, Y. (2010). Uji Aktivitas Imunostimulan Sediaan Teh Kombinasi Simplisia Kaliks Rosela (Hibiscus sabdariffa) dn Teh Pegagan (Centella asiatica) Dengan Metode Bersihan Karbon Pada Mencit [Skripsi]. Depok: Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia.
Afa, K. (2018). TheEeffects of Morinda citrifolia L. (noni) on the Immune System: its Molecular Mechanisms of Action. PubMed, Vol. 16 No.23.
Alberts B, J. A. (2012). Molecular Biology of the Cell 6th edition. New York: Garland Science.
Annisa, R. (2011). Uji Aktivitas Imunostimulan Ekstrak Etanol Umbi Sarang Semut Pada Tikus Putih Jantan [Tesis}. Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia , Depok.
Azadeh, M. V. (2015). Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. PMC, 63-72.
Baratawidjaja. (2012). Imunologi Dasar Edisi ke IX. Yogyakarta: Fakultas Kedokteran Universitas Indonesia.
Charles A Janeway, J. P. (2012). Immunobiology 8th Edition. New York: Garland Science. Churiyah. (2014). Antiviral and Immunostimulant Activities of Andrographis paniculata.
Hayati Journal of Biosciences, Vol. 22.
Denise, U. (2017). immune Modulation Properties of Herbal Plant leaves: Phyllanthus niruri Aqueous Extract on Immnue Cells of Tuberculosis Patient-in Vitro Study. Natural product Research, Vol. 32 No.4.
Elgranderie. (2010). Comparison of Immune Responses of Mice Immunized with Five Different Mycobacterium BCG Vaccines. Frontiers in Pharmacology, Vol. 01.
Fernando, C. (2017). Effect of Echinacea purpurea (Asteraceae) Aqueous Extract on Antibody Response to Bothrops asper Venom and Immune Cell Response. PubMed, Vol. 55, No.1.
Gunawan, J. R. (2013). Pengaru Pemberian Gabungan Ekstrak Phaleria dan Phyllanthus niruri Terhadap Presetasi Limfoblas Limpa Pada Mencit Balb/C. Fakultas Kedokteran Universitas Diponegoro, 1-14.
Gutierrez, J. (2015). Production of Monovalent Anti-Bothrops asper Antivenom: Development of Immune Response in Horse and Neutralizing Ability. Scielo, 22-25.
Houglum. (2013). Interferon: Mechanism of Action and Clinical Value. PubMed.
Ibrahum, J. (2019). An Insight Into the Modulatory Effects and Mechanisms of Action of Phyllanthus Species and Their Bioactive Metabolites on the Immune System. Frontiers in Pharmacology, Vol. 10.
Indrata, F. (2010). Upaya Pembuatan Teh dari Bunga Rosela (Hibiscus sabdariffa) dan Pegagan (Centella asiatica) Sebagai Sediaan Antioksidan [Skripsi]. Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok.
James, J. &. (2011). Identification and Quantification of Triterpenoid Centelloids in Centella asiatica (L.) Urban by Densitometric TLC. JPC - Journal of Planar Chromatography
- Modern TLC ·, Vol. 1, No. 1.
Lebien TW, T. T. (2010). B lymphocytes: How They Develop and Function Blood. American Society of Hematology, September, Vol. 112, No.5.
Li, S. W. (2020). The Impact of Covid-19 Epidemic Declaration on Psychological Consequences: A study on Active Weibo Users. International Journal of Environmental Research and Public Health, 19 Maret.
Marbun, R. A. (2017). Uji Efek Imunomodulator Ekstrak Etanol Herba Binara (Artemisia Vulgaris L.). Universitas Sumatera Utara, 27.
Mareta, C. A. (2020). Efektifitas Pegagan Sebagai Antioksidan. Jurnal Medika Hutama, 1-5. Michelle, C. E. (2018). Immunomodulatory Inspired by Nature: a Review on Curcumin and
Echinaceae. Molecules, 26 Oktober, Vol. 23, No. 11.
Mohammed, A. (2016). Health Benefits of Morinda Citrifolia (Noni). Pharmacogn, Vol 8, No 4.
Mukti, R. (2015). Karakterisasi Morfologi dan Anatomi Pegagan (Centella asiatica) di Kabupaten Batang Sebagai Sumber Belajar Pada Mata Kuliah Praktiikum Morfologi dan Anatomi Tumbuhan [Skripsi]. Program Studi Ilmu Pendidikan Biologi, Fakultas Tarbiyah dan Keguruan, Universitas Negeri Walisongo.
Nengah, K. (2011). Centella asitica Extract Increased on the Level of Interlukin 6 (IL-6) in Mice. Frontiers in Pharmacology.
Neni, M., Slamet, S., & Sandra, A. (2017). Respon Tanaman Pegagan Terhadap Pemberian Pupuk Alami di Bawah Naungan [Tesis]. Jurusan Pertanian, Insitut Pertanian Bogor.
Petrunov, B. N. (2017). The Role Of Immunostimulants In Immunotherapy And Immunoprophylaxis. Biotechnology & Biotechnological Equipment, 15 April, Vol. 4, No. 21.
Roit, Delver, P. J., Martin, S. J., & Burton, D. R. (2011). Roitt's Essential Immunology 6th Edition. London: Wiley-Blackwell.
Singh D, S. P. (2012). Qualitative Estimation of the Presence of Bioactive Compound in Centella Asiatica : An Important Medicine Plant. International Journal of Life Science and Medical Science, Maret, Vol. 2, No.1.
Smita, N. (2010). Immunostimulant activity of noni (Morinda citrifoloia) on T and B Lymphocyte. Pharmaceutical Biology.
Sourav Paul, G. L. (2017). The Molecular Mechanism of Natural Killer Cell Function and Its Important in Cancer Immunotherapy. Frontiers in Immunology, 4-17.
Surya, C. (2012). Effect of Pegagan Leave (Centella asiatica) Ethanol Extract on IFN-Gamma Secretion on the Spleen of Balb/C mice taht Infected with Listeria Monocytogenes. TCAM, 96-100.
Sutardi. (2016). Kandungan Bahan Aktif Tanaman Pegagan Dan Khasiatnya Untuk Meningkatkan Sistem Imun Tubuh. Jurnal Litbang Pertanian. Jurnal Litbang Pertanian, Februari, Vol. 5, No. 35.
Tjandrawinata. (2011). Clinical Trials Involving Phyllanthus species. CBC .
Ukhrowi, U. (2011). Pengaruh Pemberian Ekstrak Etanol Umbi Bidara Upas (Merremia mammosa) Terhadap Fagositosis Makrofag dan Produksi Nitrit Oksida Pada Mencit Balb/c yang Diinfeksi Salmonella thyphimurium. Universitas Diponegoro, 21.
Vaibhav, A. D. (2010). Pharmacological Study of Tinospora Cardifolia As An Immunomodulator. International Journal Of Current Pharmaceutical Research, 8 Juli, Vol.2, No.4.
Wen, W. (2010). Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Biomedcentral, Vol. 5 .
Yufri Aldi, N. D. (2016). Uji Imunomodulator dan Jumlah Sel Leukosit Dari Ekstrak Daun Kemangi (Ocimum basilicum L.). Fakultas Farmasi Andalas Padang , 2-8.
Nuraeni Anisa Dwi, Lukmayani Yani, Kodir Reza Abdul. (2021). Uji Aktivitas Antibakteri Propionibacterium acnes Ekstrak Etanol dan Fraksi Daun Karuk (Piper sarmetosum Roxb. Ex. Hunter) serta Analisis KLT Bioautografi. Jurnal Riset Farmasi, 1(1), 9-15.
DOI: http://dx.doi.org/10.29313/.v0i0.31025
