Studi Literatur Aktivitas Antibakteri Tanaman Famili Euphorbiaceae
Abstract
ABSTRACT: Infectious disease is a disease caused by the entry and development of a microorganism that can consist of fungi, bacteria, parasites and viruses. Microorganisms that can cause disease in humans are pathogenic microorganisms, and one of them is pathogenic bacteria. Plants of the Euphorbiaceae family have been used by local people in several countries in traditional medicine against several diseases. Several potential antibacterial activities of plants from the Euphorbiaceae family have been proven by several researchers, namely Jatropha (Jatropha curcas L.), chaya (Cnidoscolus aconitifolius), and meniran (Phyllanthus niruri L.). The purpose of this literature study is to find out the antibacterial activity of plants from the Euphorbiaceae family and to find out what compounds are found in plants of the Euphorbiaceae family that have antibacterial activity. This research method is carried out by means of a Systematic Literature Review (SLR) through reputable research journals. The results showed that the Euphorbiaceae family had activity against E. coli, S, aureus, K. pneumoniae, S. typhi, P. aeruginosa, and P. acnes bacteria. This activity is thought to be due to the presence of secondary metabolites of alkaloids, flavonoids, saponins, tannins, steroids, dan terpenoids. In addition, plants from the Euphorbiaceae family contain hydroxylamine, hesperidin, kaempferol, quercetin, rutin, apigenin, and philantin compounds.
Keywords: antibacterial, Euphorbiaceae family, chemical compounds
ABSTRAK: Penyakit infeksi merupakan suatu penyakit yang disebabkan oleh masuk dan berkembangnya suatu mikroorganisme yang dapat terdiri dari fungi, bakteri, dan parasit serta virus. Mikroorganisme yang dapat menyebabkan penyakit pada manusia adalah mikroorganisme patogen, dan salah satunya adalah bakteri patogen. Tanaman famili Euphorbiaceae telah digunakan oleh penduduk lokal di beberapa negara dalam pengobatan tradisional terhadap beberapa penyakit. Beberapa potensi aktivitas antibakteri dari tanaman famili Euphorbiaceae telah dibuktikan oleh beberapa peneliti yaitu pada tanaman jarak pagar (Jatropha curcas L.), chaya (Cnidoscolus aconitifolius), dan meniran (Phyllanthus niruri L.). Tujuan dari studi literatur ini mengetahui aktivitas antibakteri dari tanaman famili Euphorbiaceae dan untuk mengetahui senyawa apa saja yang terdapat pada tanaman famili Euphorbiaceae yang memiliki aktivitas antibakteri. Metode penelitian ini dilakukan secara Systematic Literatur Review (SLR) melalui jurnal penelitian bereputasi. Hasil studi menunjukkan bahwa pada tanaman famili Euphorbiaceae memiliki aktivitas terhadap bakteri E. coli, S, aureus, K. pneumoniae, S. typhi, P. aeruginosa, dan P. acnes. Aktivitas tersebut diduga karena adanya metabolit sekunder golongan alkaloid, flavonoid, saponin, tanin, steroid, dan terpenoid. Selain itu tanaman famili Euphorbiaceae memiliki kandungan senyawa hydroxylamine, hesperidin, kaempferol, kuersetin, rutin, apigenin, dan filantin.
Kata kunci: antibakteri, famili Euphorbiaceae, senyawa kimia.
Keywords
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Adeniran, et al. (2013). Phytochemical constituents, antimicrobial and antioxidant potentials of tree spinach [Cnidoscolus aconitifolius (Miller) I. M. Johnston]. Journal of Medicinal Plants Research, 7(19), 1310–1316. https://doi.org/10.5897/JMPR12.899.
Ajiboye, et al. (2018). Ethyl acetate leaf fraction of Cnidoscolus aconitifolius (Mill.) I. M. Johnst: antioxidant potential, inhibitory activities of key enzymes on carbohydrate metabolism, cholinergic, monoaminergic, purinergic, and chemical fingerprinting. International Journal of Food Properties. https://doi.org/10.1080/10942912.2018.1504787
Casals LM, Baelo A, Julian E, Astola J, Ruiz AL, Albericio F, Torrents E. (2018). Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents, ACS OMEGA;3:17057-17069.
Davis, W.W, T,.R. Stout, (1971). Disc plate methods of microbiological antibiotic assay, applied microbiology
Eka Widiadnyani, N. K., Astawa, I. N. M., Yasa, I. W. P. S., & Sukrama, I. D. M. (2021). Phytochemical test and identification of active compounds with LC-MS/MS in green Meniran leaf (Phyllanthus niruri Linn). Bali Medical Journal, 10(1), 132–136. https://doi.org/10.15562/bmj.v10i1.2208
Fitriani, E. (2014). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sirsak (Annona muricataL.) Terhadap Shigella flexneriSecara In Vitro. Naskah Publikasi. Fakultas Kedokteran Universitas Tanjungpura, Pontianak
Harti S. (2015). Mikrobiologi Kesehatan. Yogyakarta: Cv. Andi Offset.
Hendra R, S. Ahmad, A. Sukari, M.Y. Shukor, E. Oskoueian. (2011). Flavonoid analyses and antimicrobial activity of various parts of Phaleria macrocarpa (Scheff.) Boerl fruit. Int J Mol 12: 3422-3431.
Ibrahim, D., Hong, L. S., & Kuppan, N. (2013). NPC Natural Product Communications. 6–9. https://doi.org/10.1177/1934578X1300800422
Katzung, B. G., (2004). Farmakologi Dasar dan Klinik.Edisi XIII. Buku 3. Translation of Basic and Clinical Pharmacology Eight EditionAlih bahasa oleh Bagian Farmakologi Fakultas kedokteran Universitas Airlangga. Salemba Medika, Jakarta.
Kronman MP, Zhou C, Mangione-Smith R. (2014). Bacterial Prevalence and Antimicrobial Prescribing Trends For Acute Respiratory Track Infections. American Academy of Pediatrics; 134(4):956-65.
Lennox, J. A., & Egbe, G. (2018). Phytochemical compounds and antimicrobial properties of Hospital too far (Cnidoscolus Aconitifolius). Advance Research Journal of Multidisciplinary Discoveries.29(11)pp. 61-65
Madduluri S, K.B. Rao, B. Sitaram. (2013). In vitro evaluation of the antibacterial activity of five indigenous plant extract against five bacterial pathogens of humans. Pharmacy and pharmaceutical sciences. 5(4): 679-684.
Malangngi, L., Sangi, M., & Paendong, J.
(2012). Penentuan Kandungan Tanin dan Uji Aktivitas Antioksidan Ekstrak Biji Buah Alpukat (Persea americana Mill.). Jurnal MIPA, 1(1), 5.
Mandell GL, Bennet JE, Dolin R. (2007). Principles and Practice of Infectious Diseases. Elsevier Book Aid; Hal.7.
Nyam, M. A., Abdullahi, U. I., Atsen, E., Itelima, J. U., & Daniel, V. (2020). J ournal of Medical Biomedical and Applied Sciences Studies on The Antibacterial Effect of The Ethanolic Extracts of Cnidoscolus aconitifolius ( Miller ) ( Hospital Too Far ), Piliostigma thonningii ( Schum ) ( Camels Foot ) And Lantana camara (Linn)(8(2),343–351. https://doi.org/10.15520/jmbas.v8i2.212
Palanisamy, U. D., L. T. Ling, T. Mataharan, V. Sivapalan, T. Subramaniam, M. H. Helme, T. Masalamani. (2011). Standardized extract of Syzygium aqueum: A safe cosmetic ingredient. International Journal of Cosmetic Science, 33(3), pp. 269–275.
Putranti, Ristyana Ika. (2013). Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Rumput Laut Sargassum duplicatum dan Turbinaria ornata dari Jepara. [Tesis]. Universitas Diponegoro. Semarang.
Rahmawati, dkk. (2020). Gel Hesperidin dari Kulit Jeruk Manis untuk Pengobatan Ulkus Diabetikum. Jurnal Ilmiah Penalaran dan Penelitian Mahasiswa. Vol. 4 nomer 1.
Rahu, M. I., Naqvi, S. H. A., Memon, N. H., Idrees, M., Kandhro, F., Pathan, N. L., Sarker, M. N. I., & Aqeel Bhutto, M. (2021). Determination of antimicrobial and phytochemical compounds of Jatropha curcas plant. Saudi Journal of Biological Sciences, 28(5), 2867–2876.https://doi.org/10.1016/j.sjbs.2021.02.019.
Rijayanti, R.P. (2014). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Mangga Bacang (Mangifera foetidaL.) Terhadap Staphylococcus aureusSecara In Vitro. [Skripsi]. Fakultas Kedokteran Universitas Tanjungpura, Pontianak.
Raji, P., A.V. Samrot, D. Keerthana, dan S. Karishma. (2019). Antibacterial activity of alkaloids, flavonoids, saponins and tannins mediated green synthesized silver nanoparticles against Pseudomonas aeruginosa and Bacillus subtilis. Journal of Cluster Science, 30: 881-895.
Sharma, A. K., Gangwar, M., Tilak, R., Nath, G., Sinha, A. S. K., Tripathi, Y. B., & Kumar, D. (2012). Comparative in vitro antimicrobial and phytochemical evaluation of methanolic extract of root, stem and leaf of Jatropha curcas linn. Pharmacognosy Journal, 4(30), 34–40. https://doi.org/10.5530/pj.2012.30.7.
Shilpa, V., Muddukrishnaiah, K., Thavamani, Bs., Dhanapal, V., Arathi, K., Vinod, K., & Sreeranjini, S. (2018). In vitro immunomodulatory, antifungal, and antibacterial screening of Phyllanthus niruri against to human pathogenic microorganisms. Environmental Disease, 3(3), 63. https://doi.org/10.4103/ed.ed_9_18
Suhaili. Z. (2011). Antibacterial profile of Jatropha curcas latex extracts against selected human pathogenic bacteria. African Journal of Microbiology Research, 5(29), 5147–5154.
Sukmayati, dkk. (2015). Pengujian Mutu dan Penetapan Kadar Filantin pada Ekstrak Etanol Herba meniran (Phyllanthus nururi L.). Bul, Penelit, Kesehat, Vol 43.
Sukrasno, K. R., Wirasutisna & Fidrianny, I.. 2007. Pengaruh Perebusan terhadap Kandungan Flavonoid dalam Daun Singkong. Jurnal Obat Bahan Alam Vol. 6 No. 2. Jakarta.
Surahmaida, Umarudin, Rani, A. W., & Dewi1, N. C. (2021). Skrining Fitokimia Senyawa Metabolit Sekunder Ekstrak Metanol Daun Jarak Pagar ( Jatropha curcas ) dengan GCMS Phytochemical Screening of Secondary Metabolite Compounds Methanol Extract of Jatropha curcas Leaf with GCMS. Journal of Pharmacy and Science, 6(1), 25–30.
Waheed, K. et al. (2018). Antimicrobial Activity and Phytochemical Screening of Euphorbia helioscopia. Planta Daninha.
Thomas. (2007). Tanaman Obat Tradisional 2. Kanisius, Yogyakarta.
Nuraeni Anisa Dwi, Lukmayani Yani, Kodir Reza Abdul. (2021). Uji Aktivitas Antibakteri Propionibacterium acnes Ekstrak Etanol dan Fraksi Daun Karuk (Piper sarmetosum Roxb. Ex. Hunter) serta Analisis KLT Bioautografi. Jurnal Riset Farmasi, 1(1), 9-15.
DOI: http://dx.doi.org/10.29313/.v0i0.30714
