Studi Literatur Potensi Tanaman Suku Zingiberaceae Sebagai Antibakteri terhadap Shigella Dysenteriae

Silvi Adella Mandasari, Fetri Lestari, Lanny Mulqie

Abstract


ABSTRACT: Shigellosis is also called bacillary dysentery or acute diarrhea is an infectious disease caused by the bacteria Shigella dysenteriae. One alternative natural material that potential as an antibacterial is the family Zingiberaceae. The purpose of this study was to explore the potency of Zingiberacae plants, including Zingiber officinale Roscoe, Alpinia galanga (Linn.) Swartz, Zingiber roseum (Roxb.) Roscoe, Curcuma zedoaria (Chirstm.) Roscoe, and Curcuma aromatica Salisb inhibiting growth of Shigella dysenteriae bacterial and active compounds that inhibit bacterial growth. The method used in this research is systematic literature review with data sources used from various related articles from national and international journals within the last the last 10 years. The parameter observed was the inhibitory zone and value of Minimum Inhibitory Concentration (MIC). The result showed that these plants had antibacterial activity against Shigella dysenteriae and active compounds that inhibiting bacterial growth in these plants are gingerol, shagol, 1'-acetoxyeugenol acetate, zerumbone, and curcumin.

Keywords: Family Zingiberaceae, Antibacterial, Shigella dysenteriae.

ABSTRAK: Shigellosis disebut juga disenteri basiler atau diare akut yang merupakan suatu penyakit infeksi yang terjadi akibat bakteri Shigella dysenteriae. Salah satu alternatif bahan alam yang berpotensi sebagai antibakteri adalah suku Zingiberaceae. Tujuan dari penelitian ini untuk mengetahui potensi dari tanaman suku Zingiberacae meliputi, Zingiber officinale Roscoe, Alpinia galanga (Linn.) Swartz, Zingiber roseum (Roxb.) Roscoe, Curcuma zedoaria (Chirstm.) Roscoe, dan Curcuma aromatica Salisb dalam menghambat pertumbuhan bakteri Shigella dysenteriae dan senyawa aktif yang dapat menghambat pertumbuhan bakteri. Metode yang dilakukan pada penelitian ini adalah studi literatur dengan sumber data yang digunakan ialah dari berbagai pustaka yang relevan baik jurnal nasional maupun internasional dengan kriteria terbitan 10 tahun terakhir. Parameter yang diamati adalah zona bening yang terbentuk disekitar agar dan nilai Konsentrasi Hambat Minimum (KHM). Didapatkan hasil bahwa tanaman-tanaman tersebut memiliki aktivitas antibakteri terhadap bakteri Shigella dysenteriae dengan adanya zona hambat yang terbentuk disekitar agar dan terdapatnya nilai konsentrasi hambat minimum (KHM). Senyawa aktif yang berperan dalam menghambat pertumbuhan bakteri pada tanaman-tanaman tersebut seperti, gingerol, shagol, 1'-acetoxyeugenol asetat, zerumbone, dan curcumin.

Kata Kunci: Suku Zingiberaceae, Antibakteri, Shigella dysenteriae.


Keywords


Suku Zingiberaceae, Antibakteri, Shigella dysenteriae.

Full Text:

PDF

References


A. B. Akinbobola., E. O. Dada. (2014). In-vitro evaluation of the synergistic antimicrobial activities of Zingiber officinale (Rosc) and Tridax procumbens (Linn) against selected pathogenic bacteria. JMPHTR 2 : 16-22.

Amanah and Cornelli, D. (2015). Keefektifan Konsentrasi Ekstrak Jahe (Zingiber Officinale Roscoe) Terhadap Pertumbuhan Bakteri Shigella dysenteriae. Tunas Medika Jurnal Kedokteran & Kesehatan. 2(3). 1–4.

Anjusha S, Gangaprasad A (2014). Phytochemical and Antibacterial Analysis of Two Important Curcuma Species, Curcuma aromatica Salisb. And Curcuma Xanthorrhiza Roxb. (Zingiberaceae). Journal of Pharmacognosy and Phytochemistry. 3(3):50-5

Azam MG., Noman MS dan Al-Amin MM. (2014) .Phytochemical Screening andAntipyretic Effect of Curcuma zedoaria Rosc. (Zingiberaceae) rhizome. British Journal of Pharmaceutical Research. 4(5):569-575.

Cushnie, T.P.T. and Lamb, A.J. (2011). Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents, Vol. 38, No. 2: 99-107.

DeFilipps, Robert A. & Krupnick, Gary A., 2018, The medicinal plants of Myanmar, PhytoKeys 102, pp 1-341: 167.

Dosoky NS, Setzer WN. Chemical compositionand biological activities of essential oils of curcuma species. Nutrients 2018. 10(9) : 10.

Dr. Lianah, M.Pd. Biodeversitas Zingiberceae : Mijen Kota Semarang. Deepublish : Semarang.

Dr. Phoebe Williams., Prof. James A. B. (2016). Dysentery (Shigellosis) : Current WHO Guidelines and the WHO Essential Medicine List for Children. (https://www.who.int). Diunduh 27 April 2021

Ganesan S, Pandi NR, Banumathy N. 2007. Ethnomedicinal survey of Alagarkoil Hills (Reserved forest), Tamil Nadu, India. eJ Indian Med. 1: 1-18.

Goulart, F.S. (1995). Super Healing Foods. Reward Books, a member of Penguin Putnam Inc : New York.

Hartiwi Diastuti., Yana M. Syah., Lia D. Juliawaty., Marlia Singgih. (). Antibacterial Curcuma xanthorrhiza Extract and Fraction. J. Math. Fund. Sci. 46 (3) : 224-234.

Kemenkes RI. (2013). Riset kesehatan dasar. Badan Penelitian dan Pengembangan Kesehatan. Jakarta.

Lobo R, Prabhua KS, Shirwaikara A, Shirwaikarb A. (2009). Curcuma zedoaria rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. Journal of Pharmacy and Pharmacology. 61: 13–21.

M. Al-Amin., M. Arafat S., Shamima A. R., Nagla M. E., Gazi Nurun N. S., Salizawati M. S., Chowdhury F. H. (2019). Antimicrobial activity of the crude extract, fractions and isolation of zerumbone from the rhizomes of Zingiber roseum. J Res Pharm. 23(3): 559-566.

Madduluri, Suresh. Rao, K.Babu. Sitaram. (2013). B. In Vitro Evaluation of Antibacterial Activity of Five Indegenous Plants Extract Against Five Bacterial Pathogens of Human. International Journal of Pharmacy and Pharmaceutical Sciences. 5(4): 679-684

Mussaret Bano Zidi, Teresa Estrada-Gracia. (2014). Shigella : A Highly Vilurent and Elusive Pathogen. Curr Trop Med Rep. 1:81-87

N. Aligiannis., E. Kalpoutzakis., Sofia Mitaku., Ioanna B. C. (2001). Composition and Antimicrobial Activity of the Essential Oils of Two Origanum Species. J. Agric Food Chem. 49 : 4168-4170.

Niyogi, SK. (2005). Shigellosis. Journal of Microbiology, 43(2) : 133-143.

Om Prakash., V. K. Kasana., A. K. Pant., Anjum Zafar., S.K. Hore., C. S. Mathela. (2006). Phytochemical composition of essential oil from seeds of Zingiber roseum Rosc. and its antispasmodic activity in rat duodenum. Journal of Ethnopharmacology. 10(6) : 344-347.

Padal SB, Ramakrishna H, Devender R. (2012). Ethnomedicinal studies for endemic diseases by the tribes of Munchingiputtu Mandal, Visakhapatnam district, Andhra Pradesh, India. Int J Med Arom Plants. 2: 453-459.

Pratiwi, S.T. (2008). Mikrobiologi Farmasi. Edisi 5. Erlangga Medical Series. Jakarta.

Purnamasari, Devi A., Munandziroh, Elly., Yugiartono, R.M. (2010). Konsentrasi Ekstrak Biji Kakao Sebagai Material Alam dalam Menghambat Streptococcus mutans. Jurnal PDGI . 59(1).

Rahman, A. ., Afroz, M. ., Islam, K. . D. ., Rokonuzzaman, M. ., Islam, R. ., Al-Reza, S. . M. ., & Sattar, M. . A. . (2012). Chemical composition and antibacterial properties of the essential oil and organic extracts of Curcuma zedoaria Leaf. Journal of Essential Oil-Bearing Plants Jeop.

Ravindran N, Nirmal K, Sivaraman K. (2007). Tumeric the genus Curcuma. CRC Press : London, UK.

Reader’s Digest. (2004). Foods that Harm Foods that Heal. The Reader’s Digest Association Inc. New York.

Revathi S, Malathy NS. Antibacterial activity of rhizome of Curcuma aromatica and partial purification. Indian J Pharm Sci. 75:732-5.

Santoso, H.B. (2008). Ragam & Khasiat Tanaman Obat. PT Agromedia Pustaka :Yogyakarta.

Shamima Akhtar Sharmin., Mohammad J. A., Md. Mominul I. S., Rashed Z., M. Khalekuzzaman, Sanjoy C. M., M. Anwarul H., M. Firoz A., Iftekhar A. (2013). Turk J Biol. 37: 698-708.

Shrotriya, A. (2015). ‘An Introduction To Shigellosis And Strategies Against Potent Drug’. International Journal Of Pharmacy & Life Sciences. 6, 8-9.

Simay Çıkrıkçı, Erkan Mozioğlu, Hasibe Yılmaz. (2008). Biological Activity of Curcuminoids Isolated from Curcuma longa. Rec. Nat. Prod. 2(1) :19-24

Sudewo, B. (2006). Tanaman Obat Populer. Agromedia Pustaka : Yogyakarta.

Sumathi S, Iswariya GT, Sivaprabha B,Dharani B, Radha P, Padma PR. (2013). Comparative study of radical scavenging activity and phytochemical analysis of fresh and dry rhizomes of Curcuma zedoaria. IJPSR. 4(3) : 69–73.

Syarifah Nur Syed Abdul Rahman, Norhanom Abdul Wahab, Sri Nurestri Abd Malek. (2013). In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria". Evidence-Based Complementary and Alternative Medicine. vol. 2013 : 14 pages.

Tariq S., Imran M., Mushtaq Z dan Asghar N. (2016). Phytopreventive Anti Hypercholesterolmic and Antilipidemic Perspectives of Zedoary (Curcuma zedoaria Roscoe.) Herbal Tea. Lipids in Health and Disease ,15(39) : 1-1.

Tuntun, M. (2016) ‘Uji Efektivitas Ekstrak Daun Pepaya (Carica papaya L.) Terhadap Pertumbuhan Bakteri Escherichia coli dan Staphylococcus aureus’. Jurnal Kesehatan. 7(3) : 497–502.

W. W. Davis and T. R. Stout. (1971). Disc Plate Method of Microbiological Antibiotiv Assay. Appl Microbiol. 22(4): 659-665.

Warnaini, Cut. (2013). Uji efektivitas ekstrak kunyit sebagai antibakteri terhadap pertumbuhan bakteri bacillus sp. dan Shigella dysentriae secara in vitro. Jurnal Makassar, Universitas Hasanuddin.

Wei-Yea Hsu, Amarat Simonne, Alexandra Weissman, and Jeong-Mok Kim. (2010). Antimicrobial Activity of Greater Galangal [Alpinia galanga (Linn.) Swartz.] Flowers. Food Sci. Biotechnol. 19(4): 873-880.

Xixuan Tang, Changmou Xu, Yavuz Yagiz, Amarat Simonne, Maurice R. Marshall. (2018). Phytochemical profiles, and antimicrobial and antioxidant activities of Greater Galangal [Alpinia galanga (Linn.) Swartz.] flowers. Food Chemistry . 225:300-308

Zaman S, Hussain M, Nye R, et al. (2017). A Review on Antibiotic Resistance: Alarm Bells are Ringing. Cureus 9(6): e1403.

Zukhri, S et al. (2018). Uji Sifat Fisik dan Antibakteri Salep Ekstrak Daun Katuk (Sauropus androgynus (L) merr.). JIK Vol XI, No 1.

Nuraeni Anisa Dwi, Lukmayani Yani, Kodir Reza Abdul. (2021). Uji Aktivitas Antibakteri Propionibacterium acnes Ekstrak Etanol dan Fraksi Daun Karuk (Piper sarmetosum Roxb. Ex. Hunter) serta Analisis KLT Bioautografi. Jurnal Riset Farmasi, 1(1), 9-15.




DOI: http://dx.doi.org/10.29313/.v0i0.29537

Flag Counter