Kajian Pustaka Modifikasi Salinitas terhadap Kandungan Î’-Karoten Serta Aktivitas Antikanker Dunaliella Salina
Abstract
ABSTRACT: Dunaliella salina is a green microalga that lives in seawater and is known as a natural source of β-carotene. Culture media is an important in the production of D. salina biomass. One of them is salinity which influences the production of β-carotene. This study aims to determine the effect of salinity modification on the production of β-carotene content and the anticancer activity of Dunaliella salina. This research is in the form of a systematic literature review, by conducting a literature search through several publishers, namely Google Scholar, Pubmed, Taylor & Francis, Research Gate and Springer and then selecting articles that match the inclusion criteria, a total of 5 articles obtained at the main library then analyzed the data. The results showed that there was a significant effect of salt concentration in culture media on increasing Dunaliella salina β-carotene production, in hypertonic media cells would experience osmotic pressure and encourage cells to produce β-carotene as a form of self-defense. However, because of the increase in salt can reduce cell growth. With the increased production of β-carotene content, it also increases the antioxidant and anticancer activity of Dunaliella salina.
Keywords: Dunaliella salina, salinity, β-carotene, anticancer.
ABSTRAK: Dunaliella salina merupakan mikroalga hijau yang berhabitat di air laut serta dikenal sebagai penghasil sumber β-karoten alami. Media kultur berperan penting terhadap produksi biomassa D. salina. Salah satunya yaitu salinitas yang memberikan pengaruh terhadap produksi β-karoten. Penelitian ini bertujuan untuk mengetahui pengaruh modifikasi salinitas terhadap produksi kandungan β-karoten serta aktivitas antikanker Dunaliella salina. Penelitian ini berupa systematic literature review, dengan melakukan penelusuran pustaka melalui beberapa publisher yaitu Google Scholar, Pubmed, Taylor & Francis, Research Gate dan Springer lalu dilakukan seleksi terhadap artikel-artikel yang sesuai dengan kriteria inklusi, total artikel yang diperoleh 5 artikel sebagai pustaka utama kemudian dianalisis datanya. Hasil penelitian menunjukkan adanya pengaruh nyata dari konsentrasi kadar garam pada media kultur terhadap peningkatan produksi β-karoten Dunaliella salina, pada media yang hipertonis sel akan mengalami tekanan osmotik dan mendorong sel untuk memproduksi β-karoten sebagai  bentuk pertahanan diri. Namun karena adanya peningkatan garam dapat menurunkan pertumbuhan sel. Dengan meningkatnya produksi kandungan β-karoten turut meningkatkan aktivitas antioksidan serta antikanker dari Dunaliella salina.
Kata Kunci: Dunaliella salina, salinitas, β-karoten, antikanker.
Keywords
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DOI: http://dx.doi.org/10.29313/.v0i0.29310
