Studi Literatur Aktivitas Antelmintik dari Beberapa Tanaman Suku Cucurbitaceae

Hasna Afifah Yudantika, Suwendar Suwendar, Fetri Lestari

Abstract


ABSTRACT: In Indonesia, intestinal worms are still relatively high, especially among people with densely populated residences, poor sanitation, lack of toilets, and inadequate clean water facilities. Cucurbitaceae plants that have potential as anthelmintics are bitter melon (Momordica charantia L), yellow pumpkin (Cucurbita moschata Duchesne), melon (Cucumis melo), zucchini (Cucurbita pepo), cucumber (Cucumis sativus Linn), and thummittikai (Cucumis trigonus Roxb). The purpose of this literature study was to determine the anthelmintic activity of Cucurbitaceae plants against several types of worms and to determine the class of secondary metabolites contained which have anthelmintic activity by research methods in the form of literature searches in the form of national and international journals related to anthelmintics and the Cucurbitaceae tribe. Cucurbitaceae plants that have potential as anthelmintics are bitter melon (Momordica charantia L), yellow pumpkin (Cucurbita moschata Duchesne), melon (Cucumis melo), zucchini (Cucurbita pepo), cucumber (Cucumis sativus Linn), and thummittikai (Cucumis trigonus Roxb). The result obtained showed that the six plants of the Cucurbitaceae tribe had anthelmintic activity seen from the Ascaris suum, Ascaridia galli, and Pheretima posthuma worms activity paralysis and death at a certain time. Secondary metabolites contained in six plants of the Cucurbitaceae tribe are saponins, tannins, flavonoids, glycosides, terpenoids, phenols, and alkaloids. The conclusion from this literature study is that the six plants of the Cucurbitaceae tribe have anthelmintic activity and The secondary metabolite compounds contained are saponins, tannins, flavonoids, glycosides, terpenoids, phenols, and alkaloids which have anthelmintic activity.

Keywords: Anthelmintic, Worm infection, Cucurbitaceae, Secondary metabolites

ABSTRAK: Di Indonesia, penyakit cacingan masih tergolong tinggi, terutama di kalangan masyarakat dengan tempat tinggal yang padat penduduk, sanitasi yang buruk, tidak adanya toilet dan fasilitas air bersih yang kurang memadai. Tanaman suku Cucurbitaceae yang berpotensi sebagai antelmintik adalah pare (Momordica charantia L), labu kuning (Cucurbita moschata Duchesne), melon (Cucumis melo), zukini (Cucurbita pepo), mentimun (Cucumis sativus Linn), dan thummittikai (Cucumis trigonus Roxb). Tujuan dari dilakukannya studi literatur ini adalah untuk mengetahui aktivitas antelmintik dari tanaman suku Cucurbitaceae terhadap beberapa jenis cacing dan mengetahui golongan senyawa metabolit sekunder yang terkandung yang memiliki aktivitas antelmintik dengan metode penelitian berupa penulusuran pustaka berupa jurnal nasional dan internasional yang berkaitan dengan antelmintik dan suku Cucurbitaceae. Hasil yang didapatkan menunjukkan bahwa keenam tanaman suku Cucurbitaceae memiliki aktivitas antelmintik dilihat dari aktivitas cacing Ascaris suum, Ascaridia galli dan Pheretima posthuman yang mengalami paralisis dan juga kematian pada waktu tertentu. Golongan senyawa metabolit sekunder yang terkandung dalam keenam tanaman suku Cucurbitaceae yaitu saponin, tanin, flavonoid, glikosida, terpenoid, fenol, dan alkaloid. Kesimpulan dari studi literatur ini bahwa keenam tanaman suku Cucurbitaceae memiliki aktivitas antelmintik dan golongan senyawa metabolit sekunder yang terkandung yaitu saponin, tanin, flavonoid, glikosida, terpenoid, fenol, dan alkaloid memiliki aktivitas antelmintik.

Kata Kunci: Antelmintik, Infeksi cacing, Cucurbitaceae, Metabolit sekunder


Keywords


Antelmintik, Infeksi cacing, Cucurbitaceae, Metabolit sekunder

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References


Comparison of Chinese and American Indian (Chumash) Medicine. Evid Based Complement Alternat Med 7(2): 219-225.

Amer, R., Abdel Aziza., Mahmoud R., Abou Lailab., Mohammad Azizc., Mosaab A., Omard., Khaled Sultan. (2018). In vitro and in vivo anthelmintic activity of pumpkin seeds and pomegranate peels extracts against Ascaridia galli. Beni-Suef University, Mesir.

Astuti, K. W., Samirana, P. O., Sari, N. P. E. (2016). Uji Daya Anthelmintik Ekstrak Etanol Kulit Batang Lamtoro (Leucaena leucocephala (Lam.) De Wit) Pada Cacing Gelang Babi (Ascaris suum Goeze) Secara In Vitro. Jurnal Farmasi Udayana, Bali. Vol. 5, No. 1, Col. 15–19.

Bisognin, D.A. (2002). Origin and Evolution of Cultivated Cucurbits. Ciência Rural, Santa Maria 32 (5): 715-723.

Budiyanti, R.T., Murkati., Qadrijati, I. (2016). Efek Antihelmintik Infusa Herba Sambiloto (Andrographis paniculata) Terhadap Ascaris suum Secara In Vitro. Bioteknologi, 13(2), 73-82.

Departemen Kesehatan Republik Indonesia. (2015). Sistem Kesehatan Nasional. Jakarta.

Feitosa, T.F., Vilela, V.L.R., Athayde, A.R., Braga, F.R., Dantas, E.S., Vieira, V.D., de Melo, L.R.B. (2013). Anthelmintic Efficacy of Pumpkin Seed (Cucurbita pepo Linnaeus, 1753) on Ostrich Gastrointestinal Nematodes in a Semiarid Region of Paraíba State Brazil. Trop. Anim. Health Prod. 45, 123–127.

Grover, J.K., Yadav, S.P. (2004). Pharmacological Actions and Potential Uses of Momordica charantia: a review. J. Ethnopharmacol. 93, 123–132.

Hamzah, A., Hambal, M., Balqis, U., Athaillah, F. (2016). In Vitro Anthelmintic Activity of Veitchia merrillii Nuts Against Ascaridia galli. Traditional Medicine Journal, Vol. 21, No. 2, Col. 55-62.

Haryatmi, D., Astirin, O.P., Widiyani, T. (2017). Aktivitas Vermisidal dan Ovisidal dari Buah Pisang Ambon (Musa paradisiaca var. sapentum L.) terhadap Cacing Ascaris suum secara in vitro. Seminar Nasional Pendidikan Sains. Universitas Sebelas Maret Surakarta, Surakarta ;293-8.

Hson, M.C., Paul, P.H., Sih, C.Y. (2001). Pharmacology and Applications of Chinese and Material Medical. World Scientific, Singapura.

Jain, P., Singh, S. (2013). Anthelmintic Pontential of Herbal Drugs. Internatiol J. Res. Dev. Pharm. Life Sci.;2:412–427.

Mahatriny, N. N., Payani, N. P. S., Oka, I. B. M., & Astuti, K. W. (2014). Skrining Fitokimia Ekstrak Etanol Daun Pepaya (Carica papaya L.) Yang Diperoleh dari Daerah Ubud, Kabupaten Gianyar, Bali. Jurnal Ilmiah Kefarmasian, 12.

Maria, Y.N., Tjokropranoto, R., Rosnaeni, Nathania. (2011). Anthelmintic Effect of Ethanol Extract of Pare Leaf (Momordica charantia) Against Female Ascaris Suum Warm in vitro. Jurnal Medika Planta. 1 (4). Halaman 33-39.

Milla, L.R., Suwendar., Ratu Choesrina. (2020). Telaah Pustaka Uji Aktivitas Antelmintik Terhadap Mentimun (Cucumis sativum L). Prodi Farmasi, FMIPA UNISBA, Bandung.

Mela, S.R., Sri Peni, F., Siti Hazar. (2020). Studi Literatur Aktivitas Antelmintik dari Beberapa Tanaman Suku Apicieae. Prodi Farmasi, FMIPA UNISBA, Bandung.

Meng Xiaoyun., Munishkina Larissa A., Fink Anthony L., Uversky Vladimir N. (2010). Effects of Various Flavonoids on The Alfa-Synuclein Fibrillation Process Parkinson’s Disease. Hindawi Publishing Corporation, Cairo, Egypt.

Noni, Z., Vonna, A., T, Maulana., Faridah, H. (2020). Ekstrak Etanol Biji Labu Kuning (Cucurbita moschata Duschene) Sebagai Antelmintik pada Cacing Gelang (Ascaridia galli). Jurusan Farmasi, Poltekkes Kemenkes Aceh, Banda Aceh.

Noor, Rasuane dan Asih, T. (2018). Tumbuhan Obat di Suku Semendo Kecamatan Way Tenong Kabupaten Lampung Barat. Penerbit Laduny, Lampung.

Peter Karlovsky. (2008). Secondary Metabolites in Soil Ecology. Springer, Heidelberg, Germany. p. 215.

Rahmalia, A.D. (2010). Efek Anthelmintik Infusa Biji Kedelai Putih (Glycine max (L) Merril) terhadap Waktu Kematian Cacing Gelang Babi (Ascaris suum Goeze) In Vitro. Fakultas Kedokteran Universitas Sebelas Maret, Surakarta.

Rashmi, V., Trivedi., Kamlesh, J., Wadher., Jayashri, B., Taksande., Milind, J. Umekar. (2011). Bitter melon: a Bitter Body with Sweet Soul. International Journal of Research in Ayuverda and Pharmacy. IJRAP, New Delhi, India Vol 2 (2). p. 443-447.

Singh, N., Sharma, B. (2018). Toxicological Effects of Berberine and Sanguinarine. Front Mol Biosci. Vol. 5, No. 21, pp. 1-7.

Soedarto. (2010). Parasitologi Klinik. Airlangga University Press, Surabaya.

Subarayan Bothi Gopalakrishnan., Thangaraj Kalaiarasi., Ealumalai Vadivel. (2014). In Vitro Anthelmintic Screening Comparison of Various Crude Extracts of The Fruits of Cucumis Trigonus Roxb and Cucumis Sativus Linn. World Journal of Pharmaceutical Research, India.

Surya, A. (2011). Dasar Parasitologi Klinis. Gramedia, Jakarta.

Syarif, Amir dan Elysabeth. (2011). Antelmintik. Dalam: S.G. Gunawan, R. Setiabudy, Nafrialdi, editor, Farmakologi dan Terapi Edisi 5. Departemen Farmakologi dan Terapeutik Fakultas Kedokteran, Universitas Indonesia, Jakarta.

Urban, J., Kokoska, L., Langrova, I., and Matejkova, J. (2008). In Vitro Anthelmintics Effects of Medicinal Plants Used in Czech Republic. Pharmaceutical biology. Halaman : 808-813.

Veer, B., Mohd, Junaid., Heena, F. (2018). Anthelmintic Activity of Pulp and Seed Extracts of Cucumis melo L. School of Pharmaceutical Science, Shri Venkateshwara University, NH # 24, Delhi Kanpur Highway, Gajraula, Amroha, UP, India.

Abdurrozak Mohammad Ihsan, Syafnir Livia, Sadiyah Esti Rachmawati. (2021). Uji Efektivitas Ekstrak Etanol Daun Angsana (Pterocarpus Indicus Willd) sebagai Biolarvasida terhadap Larva Nyamuk Culex Sp. Jurnal Riset Farmasi, 1(1), 33-37.




DOI: http://dx.doi.org/10.29313/.v0i0.29164

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