Studi Literatur Emulgel sebagai Pembawa Agen Tabir Surya Alami Senyawa Golongan Flavonoid

Syifa Ari Suciyani, Ratih Aryani, Gita Cahya Eka Darma

Abstract


Abstract. One of the natural sunscreen agents is a flavonoid compound which can be made into emulgel dosage forms. The purpose of this study was to determine the effectiveness of sunscreens from flavonoid types and the efforts that must be considered in sunscreen emulgel preparations that meet the requirements. This research was conducted using the literature review method. The type of flavonoid compound that is most effective as a natural sunscreen agent has an OH group at position 3 ', 4' on ring B and position 3 on ring C, because it can act as a strong antioxidant, it can help protect the skin from radiation caused by ultraviolet rays. In emulgel preparations that must be considered are emulgators and gelling agents which will increase viscosity of the emulgel preparation so that the stability of the emulgel preparation is better and the adhesion of the preparation increases so that it protects the skin from ultraviolet radiation in a relatively longer time.

Keywords: Ultraviolet light, sunscreen, flavonoids, antioxidant, emulgel.

Abstrak.Salah satu agen tabir surya alami  adalah senyawa flavonoid yang dapat dibuat ke dalam bentuk sediaan emulgel. Tujuan penelitian ini untuk mengetahui efektifitas tabir surya dari jenis flavonoid serta upaya yang harus diperhatikan dalam sediaan emulgel tabir surya  yang memenuhi persyaratan.  Penelitian ini dilakukan dengan menggunakan metode review literatur. Jenis senyawa flavonoid yang paling efektif sebagai agen tabir surya alami yang memiliki gugus OH pada posisi 3’, 4’ pada cincin B serta posisi 3 pada cincin C, karena dapat berperan sebagai antioksidan yang kuat sehingga dapat membantu melindungi kulit dari radiasi akibat sinar ultraviolet. Pada sediaan emulgel yang harus diperhatikan adalah emulgator dan gelling agent yang akan meningkatkan viskositas sediaan emulgel sehingga stabilitas sediaan emulgel menjadi lebih baik dan daya lekat sediaan meningkat sehingga melindungi kulit dari radiasi sinar ultraviolet dalam waktu relatif lebih lama.

Kata Kunci: Sinar ultraviolet, tabir surya, flavonoid, antioksidan, emulgel.


Keywords


Sinar ultraviolet, tabir surya, flavonoid, antioksidan, emulgel.

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References


Ajazuddin, Alexander, A., Khichariya, A., Gupta, S., Patel, R. J., Giri, T. K., & Tripathi, D. K. (2013). Recent expansions in an emergent novel drug delivery technology: Emulgel. JCR, 171(2), 122–132.

Amic, D., Davidovic-Amic, D., Beslo, D., & Trinajstic, N. (2003). Structure-radical scavenging activity relationships of flavonoids. CCA, 76(1), 55–61.

Asirvatham, R., & Christina, A. J. M. (2018). Antioxidant potential of Drosera indica L in Presence of Dalton Ascites lymphoma (DAL) tumor in mice. IJP, 29(3), 127–135.

Barry, B. W., (1983), Dermatological Formulation, Mercel Dekker inc., New York, pp. 300-304.

Begum, S. G., Chetty, C. M., Pavithra, B., Akhila, B., Gayathri, C., Ruksar, S., Sravani, T., & Voleti, V. K. (2019). A Review on Emulgels-A Novel Approach for Topical Drug Delivery. AJPRD, 7(2), 70–77.

Cefali, L. C., Ataide, J. A., Moriel, P., Foglio, M. A., & Mazzola, P. G. (2016). Plant-based active photoprotectants for sunscreens. IJCS, 38(4), 346–353.

Chen, L., Hu, J. Y., & Wang, S. Q. (2012). The role of antioxidants in photoprotection: A critical review. JAAD, 67(5), 1013–1024.

Daud, N. S., Akbar, A. J., Nurhikma, E., & Karmilah, K. (2018). Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling Agent. BJP, 1(2), 64–67.

Dewi, Y. N., Mulyanti, D., & Maulana, I. T. (2015). Optimasi Formulasi Basis Sediaan Emulgel dengan Variasi Konsentrasi Surfaktan. Prosiding Penelitian Sivitas Akademika Unisba, 287–291.

Goulart, J. M., Wang, S. Q., Meloni, M., & Stanfield, J. (2010). UVA protection labeling and in vitro testing methods. PPS, 9(4), 516–523.

Kumar, S., & Pandey, abhay K. (2013). Chemistry and Biological Activities of Flavonoids: An Overview Shashank. TSWJ, 58(4), 1–16.

Lachman, L., Lieberman, H.A., and Kanig, J.L. (1986). The Theory and Practice of Industrial Pharmacy,2nd ed., Lea and Febiger, Philadelphia. 648 – 659.

Lee, M.H., Baek, M.H., Cha, D.S., Park, H.J., and Lim, S.T. (2002). Freeze-thaw Stabilization of Sweet Potato Starch Gel by Polysaccaride Gums. Food Hydrocolloids, 16, p. 346.

Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals , antioxidants and functional foods : Impact on human health. Pharmacognosy Reviews, 4(8), 118–126.

Matsui, M. S., Hsia, A., Miller, J. D., Hanneman, K., Scull, H., Cooper, K. D., & Baron, E. (2009). Non-Sunscreen Photoprotection : Antioxidants Add Value to a Sunscreen. JIDSP, 14(1), 56–59.

Merisca, S. (2014). Carbopol 940 Sebagai Gelling Agent Terhadap Sifat Fisik Dan Stabilitas Fisik Kirim Sunscreen Fraksi Etil Asetat Daun Jambu Biji (Psidium guajava L.). Universitas Sanata Dharma, Fakultas F(Univ. Sanata Dharma), Yogyakarta.

Ngoc, Tran, Moon, Chae, Park, & Lee. (2019). Recent Trends of Sunscreen Cosmetic: An Update Review. Cosmetics, 6(64), 1–15.

Nur, S., Sami, F. J., Awaluddin, A., & Afsari, M. I. A. (2019). Korelasi Antara Kadar Total Flavonoid dan Fenolik dari Ekstrak dan Fraksi Daun Jati Putih (Gmelina Arborea Roxb.) Terhadap Aktivitas Antioksidan. JFG, 5(1), 33–42.

Nurdianti, L., & Aji, N. (2018). Evaluasi Sediaan Emulgel Anti Jerawat Tea Tree (Melaleuca alternifolia) Oil Dengan Menggunakan HPMC Sebagai Gelling Agent. JP, 1(1), 23–31.

Panchal, B., & Rathi, S. (2018). Topical Emulgel: a Review on State of Art. IJPS, 9(1), 253–264.

Pena, L. E., (1990), Gel Dosage Form: Theory, Formulation and Processing In Osborne, D. W., and Amann, A. H., Topical Drug Delivery Formulations, Marcell Dekker, New York, pp. 381-387.

Pratama, W. A dan Zulkarnain, A. K., 2015, Uji SPF In Vitro dan Sifat Fisik Beberapa Produk Tabir Surya yang Beredar di Pasaran, Majalah Farmaseutik, 11 (1): 2

Priani, S. E., Humanisya, H., & Darusman, F. (2014). Development of Sunscreen Emulgel Containing Cinnamomum Burmannii Stem Bark Extract. IJSR, 3(12), 2338–2341.

Putranti, W., Maulana, A., & Fatimah, S. F. (2019). Formulasi Emulgel Ekstrak Bawang Putih (Allium sativum L.). JSFK, 6(1), 7–15.

Putri, Y. D., Kartamihardja, H., & Lisna, I. (2019). Formulasi dan Evaluasi Losion Tabir Surya Ekstrak Daun Stevia ( Stevia rebaudiana Bertoni M ). JSFK, 6(1), 32–36.

Rerung, F., Anam, S., & Khumaidi, A. (2017). Isolasi Senyawa Flavonoid Ekstrak Biji Pinang Merah (Areca vestiaria Giseke) dan Uji Sitotoksiknya Melalui Uji Brine Shirimp Lethality Test (BSLT). GJP, 3(1), 18–26.

Rowe, R.C., Paul J.S., and Marian E.Q. (2009). Handbook of Pharmaceutical Excipients, Sixth Edition, Pharmaceutical Press and the American Pharmacists Association Press, London.

Saewan, N., & Jimtaisong, A. (2013). Photoprotection of natural flavonoids. JAPS, 3(9), 129–141.

Saraswaty, V. (2010). Alpha Glucosidase Inhibitory Activity From Syzigium sp. JTI, 33(1), 33–37.

Simon, Patrisia. (2012). Formulasi Dan Uji Penetrasi Mikroemulsi Natrium Diklofenak Dengan Metode Sel Difusi Franz Dan Metode Tape Stripping. Skripsi. Prodi Farmasi FMIPA Universitas Indonesia, Depok.

Sharma, V., Nayak, S. K., Paul, S. R., Choudhary, B., Ray, S. S., & Pal, K. (2018). Emulgels. Polymeric Gels, 252–264.

Sharon, N., Anam, S., Yuliet. (2013). Formulasi Krim Ekstrak Etanol Bawang Hutan [Eleutherine palmifolia L. (Merr)]. OJNS, 2(3): 111-122.

Shenoy, P. A., Khot, S. S., Chavan, M. C., Takawale, J. V, & Singh, S. (2010). Study of sunscreen activity of aqueous , methanol and acetone extracts of leaves of Pongamia pinnata ( L .) Pierre , Fabaceae. IJGP, 132, 270–274.

Sunarni, T., Pramono, S., & Asmah, R. (2007). Flavonoid antioksidan penangkap radikal dari daun kepel ( Stelechocarpus burahol ( Bl .) Hook f . & Th .) Antioxidant – free radical scavenging of flavonoid from The. MFI, 18(3), 111–116.

Susanti Vh, E., Utomo, S. B., Syukri, Y., & Redjeki, T. (2012). Phytochemical Screening And Analysis Polyphenolic Antopxidant Activity Of Methanolic Extract Of White Dragon Fruit (Hylocereus undatus). IJP, 23(1), 60–64.

Wang, T. yang, Li, Q., & Bi, K. shun. (2018). Bioactive flavonoids in medicinal plants: Structure, activity and biological fate. AJPS, 13(1), 12–23.

Yadav, S. K., Mishra, M. K., Tiwari, A., & Shukla, A. (2016). Emulgel: a New Approach for Enhanced Topical Drug Delivery. IJCPR, 9(1), 15.

Zheng, Y., Deng, G., Liang, Q., Chen, D., Guo, R., & Lai, R. (2017). Antioxidant Activity of Quercetin and Its Glucosides from Propolis : A Theoretical Study. Scientific Reports, 7(7543), 1–11.




DOI: http://dx.doi.org/10.29313/.v6i2.24258

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