Review Artikel: Uji Aktivitas Antimikroba Ekstrak Daun Daruju (Acanthus ilicifoius L.) terhadap Beberapa Macam Bakteri Patogen
Abstract
Abstract. Daruju leaves are herbs that are empirically used to treat skin disorders, so it is thought to have antibacterial activity. Antibacterial is a compound that can inhibit cell wall synthesis, inhibit protein synthesis and inhibit the work of bacterial enzymes. There are various bacteria that can be curtailed by daruju leaves such as positive Gram and negative Gram bacteria. The study is a literature study, which is aimed at figuring out how the daruju zone responds to positive Gram and negative Gram pathogens, as well as knowing which pathogens the daruju leaves can suppress. Data obtained is the most effective diameter of the blockage zone of positive Gram bacteria and the minimum value of KHM and KBM by producing a 1 mg/mL and 3 mg/mL of bacteria containing the daruju leaf. According to literature, the metabolic compounds contained in daruju leaves consist of saponin, polyphenols, tannin, terpenids, flavonoid, anthrax and alkaloids.
Keyword: Daruju leaves, Gram bacteria positive, Gram bacteria negative, Antibacterial.
Abstrak. Daun daruju merupakan tanaman herbal yang secara empiris digunakan untuk pengobatan gangguan kulit, sehingga diduga memiliki aktivitas antibakteri. Antibakteri merupakan senyawa yang dapat menghambat sintesis dinding sel, menghambat sintesis protein dan menghambat kerja enzim bakteri. Terdapat beberapa macam bakteri yang dapat dihambat oleh daun daruju seperti bakteri Gram positif dan Gram negatif. Penelitian ini bersifat studi literatur, yang bertujuan untuk mengetahui bagaimana perbandingan zona hambat daun daruju terhadap bakteri patogen gram positif dan gram negatif, serta mengetahui bakteri patogen apa saja yang dapat dihambat oleh daun daruju. Data yang didapat berupa diameter zona hambat yang paling efektif terhadap bakteri Gram positif serta nilai KHM dan KBM paling minimum dengan menghasilkan zona hambat 1 mg/mL dan 3 mg/mL terhadap bakteri P. aeruginosa yang berarti daun daruju mampu berpotensi sebagai antibakteri. Menurut literatur, kandungan senyawa metabolit yang terkandung didalam daun daruju terdiri dari saponin, polifenol, tanin, terpenoid, flavonoid, antrakuinon dan alkaloid.
Kata kunci: Daun daruju, Bakteri Gram positif, Bakteri Gram Negatif, Antibakteri.
Keywords
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DOI: http://dx.doi.org/10.29313/.v6i2.24095
