Bioprospeksi Potensi Aktivitas Sitotoksik Gandasoli Hutan (Hedychium roxburghii BI) Berdasarkan Studi Kemotaksonomi Genus Hedychium spp
Abstract
Abstract. Rhizomes from plants of the genus Hedychium are known to have potential cytotoxic activity. Some species of these plants are H. coronarium, H. spicatum, H. ellipticum, H. forestii, H. longipetalum, H. gardenerianum, H. yunnanense and H. roxburghii. Information about the potential cytotoxic activity of the H. roxburghii rhizome is unknown at this time. So the purpose of this research is to knowing the potential cytotoxic activity of the H. roxburghii rhizome based on the bioprospection of chemotaxonomic studies of the genus Hedychium spp. The results showed that the rhizomes of H. coronarium, H. spicatum, H. ellipticum, H. forestii, H. longipetalum, H. gardenerianum and H. yunnanense have similar chemical content to each other that have potential cytotoxic activity. This is based on LC50 values obtained using the BSLT (Brine Shrimp Lethality Test) and MTT (Microculture Tettrazolium Salt) methods. So from this, chemical compounds that have the potential for cytotoxic activity contained in the rhizomes of various plants of the genus Hedychium, may also be contained in the rhizome of H. roxburghii Then the rhizome can be said to have the potential for cytotoxic activity as well
Keyword: Rhizome of Hedychium, Cytotoxic
Abstrak. Rimpang tumbuhan dengan genus Hedychium diketahui memiliki potensi aktivitas sitotoksik. Beberapa diantaranya spesies dari tumbuhan tersebut adalah H. coronarium, H. spicatum, H. ellipticum, H. forestii H. longipetalum, H. garderianum, H. yunnanense dan H. roxburghii. Namun terkait informasi potensi aktivitas sitotoksik dari rimpang H. roxburghii belum diketahui hingga saat ini. Sehingga tujuan dilakukannya penelitian ini adalah untuk mengetahui potensi aktivitas sitotoksik dari rimpang H. roxburghii berdasarkan bioprospeksi studi kemotaksonomi terhadap genus Hedychium spp. Hasilnya menunjukkan bahwa pada rimpang tumbuhan H. coronarium, H. spicatum, H. ellipticum, H. forestii H. longipetalum, H. garderianum dan H. yunnanense memiliki kemiripan kandungan senyawa kimia antar satu sama lain yang berpotensi sitotoksik. Hal ini berdasarkan nilai LC50 yang diperoleh menggunakan metode metode BSLT (Brine Shrimp Lethality Test) dan MTT Microculture Tettrazolium Salt) assay. Sehingga dari hal tersebut, kemungkinan senyawa yang berpotensi sitotoksik yang terkandung dalam rimpang berbagai tumbuhan dari genus Hedychium spp juga terkandung pula pada rimpang tumbuhan gandasoli hutan (H. roxburghii). Maka kemungkinan rimpang tumbuhan gandasoli hutan (H. roxburghii) ini juga berpotensi memiliki aktivitas sitotoksik.
Kata kunci: Rimpang Hedychium, Sitotoksik.
Keywords
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Cronquist, A. (1981). An Integrated System of Classification of Flowering Plants, Columbia Press, New York.
Hartati, R., Asep, G. S., and Irda, F. (2014). ‘Botanical, Phytochemical and Pharmacological Properties of Hedychium (Zingiberaceae) - A Review’. Elsevier : Procedia Chemistry, Vol. 13.
Hartati, R., Asep, G. S., and Irda, F. (2015). ‘Chemical Composition And Antimicrobial Activity Of Diterpene And Essential Oils Of Hedychium roxburghii Blume Rhizome’, Asian J Pharm Clin Res, June, Vol.8, No.5.
Meyer, B. N. et al. (1982). ‘Brine shrimp: a convenient general bioassay for active plant constituents’. Planta Medica, Mei, Vol. 45 No.1.
Pancharoen, O., Kelvin, P., Reutrakul, V., Taylor, W.C., and Tuntiwachwuttikul, P. (2000). ‘Phytochemistry of the Zingiberaceae’. Aust. J. Chem, Vol. 40, No. 3.
Ram, Singh, and Geetanjali. (2018). ‘Chemotaxonomy of Medicinal Plants: Possibilities and Limitations’, Elsevier Ltd.
Reddy, P. P, et al. (2009) ‘Two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum’, Elsevier : Bioorganic & Medicinal Chemistry Letters, May, Vol. 19.
Saudah, et al. (2017). ‘Eksplorasi Spesies Tumbuhan Berkhasiat Obat Berbasis Pengetahuan Lokal Di Kabupaten Pidie’ Jurnal Tumbuhan Obat Indonesia, Desember, Vol. 12, No.2.
Seikh, Z., and Dash, P.R. (2015) ‘Preliminary studies on phytochemicals and cytotoxic activity of methanolic rhizome extract of Hedychium coronarium’, Journal of Pharmacognosy and Phytochemistry, Maret, Vol. 4, No, 1..
Sineenard, S. and Nuchnipa, N. (2016).’Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm’, molecules, June, Vol.21.
Suresh, G., Reddy, P., Suresh, B. K., Shaik TB., Kalivendi, S.V. (2010). ‘Two New Cytotoxic Labdane Diterpenes From The Rhizomes Of Hedychium coronarium’, Bioorg Med Chem Lett 2010; 20: 7544–48.
Suresh, G, et al. (2013) ‘Cytotoxic Sesquiterpenes From Hedychium spicatum: Isolation, Structure Elucidation And Structure–Activity Relationship Studies’, Elsevier: Fitoterapia, February.
Thomas, E, et al. (2016).’Biopiracy Of Natural Products And Good Bioprospecting Practice’, Phytomedicine, December.
Wilson, R. T., Maria, do, C.B. and Ana M. L. S. (2020).’Uncharted Source of Medicinal Products: The Case of the Hedychium Genus’, Medicines, April, Vol. 7, No. 23.
Yu-Peng Li, et al. (2016). ‘New Labdane Diterpenes From Hedychium yunnanense With Cytotoxicity And Inhibitory Effects On Nitric Oxide Production’,Natural Product Research, September, Vol. 30, No. 23.
Zhao, H, et al. (2015).’Cytotoxic Labdane-Type Diterpenes From Hedychium longipetalum Inhibiting Production Of Nitric Oxide’, Elsevier : Bioorganic & Medicinal Chemistry Letters, August.
DOI: http://dx.doi.org/10.29313/.v6i2.23887
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