Scoping Review: Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non Formularium Nasional
Abstract
Abstract. Scabies is a skin disease that is caused by Sarcoptes scabiei var hominis mite. In Indonesia, scabies is the third of the 12 most common skin disease. Eleven factors can influence scabies prevalence, failure of treatment is one of the factors. This research aims to understand the comparison of antiscabietic drugs in National Formulary with Non-National Formulary. The method of this research is a scoping review that was done in September 2020–December 2020. The systematic search was done from electronic databases i.e. PubMed, Science Direct, Springerlink, Google Scholar, and Cochrane. Per the inclusion and exclusion criteria and PICOS (Patient, Intervention, Comparison, Outcome, and Study) criteria. From database searches, 17 articles are included. From 17 articles, 12 articles show that Permethrin has better cure rate than Benzyl Benzoate, Ivermectin, Gamma benzene hexachloride and Crotamiton. Two articles show that Ivermectin has higher cure rate than Lindane and Sulfur. One article suggests sulfur combination therapy is preferable to single therapy. One article shows that Tinospora cordifolia has a high cure rate. One article shows that Afoxolaner can be used as an antiscabies drug. The conclusion is that Permethrin has a high cure rate, so Permethrin can be used as the main therapy for scabies.
Keyword: Antiscabietic drugs, National Formulary, Scabies
Abstrak. Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, Skabies merupakan urutan ketiga dari 12 penyakit kulit tersering. Terdapat sebelas faktor yang bisa memengaruhi prevalensi skabies di suatu komunitas salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional dengan Non formularium Nasional. Metode pada penelitian ini adalah scoping review yang dilakukan dari September 2020–Desember 2020. Pencarian sistematis dilakukan melalui database elektronik yaitu PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane. Sesuai dengan kriteria inklusi dan eksklusi serta dilakukan skrining menggunakan kriteria PICOS (Pasien, Intervention, Comparison, Outcome, dan Study). Dari hasil pencarian, terdapat 17 artikel yang sesuai dengan kriteria. Dari 17 artikel, 12 artikel menunjukan bahwa Permethrin merupakan obat yang memiliki cure rate lebih baik daripada Benzyl Benzoate, Ivermectin, Gamma benzene hexachloride dan Crotamiton. Dua artikel menunjukan Ivermectin memiliki cure rate lebih tinggi daripada Lindane dan Sulfur. Satu artikel menunjukan terapi kombinasi sulfur lebih baik daripada terapi tunggal. Satu artikel menunjukan bahwa Tinospora cordifolia memiliki cure rate yang tinggi. Satu artikel menunjukan bahwa Afoxolaner dapat dijadikan obat antiskabies. Sehingga, dapat disimpulkan bahwa cure rate Permethrin tinggi, sehingga Permethrin dapat dijadikan terapi utama untuk skabies.
Kata kunci: Obat antiskabies, Formularium Nasional, Skabies
Keywords
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DOI: http://dx.doi.org/10.29313/kedokteran.v7i1.26746
