Scoping Review: Pengaruh Paparan Komponen Bensin terhadap Kerusakan Hepar Rattus
Abstract
Abstract. There has been an increase in the number of vehicles in Indonesia by 5-6% per year from 2014 to 2016 based on data published by the Central Statistics Agency. The impact of the increase in motorized vehicles will also increase the use of gasoline. Gasoline has toxic content, namely benzene, toluene, xylene, and lead. Exposure to gasoline is often associated with health problems, one of which is the liver. The purpose of this study was to determine the effect of exposure to gasoline components or its metabolites on damage to the liver structure of rats. This study uses the Scoping Review method to analyze, identify and evaluate scientific articles that match the inclusion and exclusion criteria. This study conducted screening using Eligibility Criteria with the population used by rats, gasoline exposure intervention, comparison of normal mice that were not exposed to gasoline and the outcome of damage to the rats' liver structure so that 936 articles were obtained and there were nine articles that met the eligibility. The results of this study indicate that there are changes in the hepatic cell structure of rats characterized by necrosis, inflammation, and enlargement of the hepatic portal vein. The conclusion of this study shows that there is an effect of exposure to gasoline components or its metabolites on the damage to the liver structure of rats by showing degenerative changes, necrosis, and the widening of the hepatic portal vein.
Keyword: Gasoline, Liver structure damage, Rats
Abstrak. Peningkatan pada jumlah kendaraan di Indonesia sebesar 5-6% per tahunnya sejak 2014 sampai 2016 bedasarkan data yang dipublikasikan oleh Badan Pusat Statistik. Dampak dari peningkatan kendaraan bermotor akan meningkatkan juga dari penggunaan bensin. Bensin memiliki kandungan toksik yaitu benzene, toluene, xylen, dan lead. Paparan bensin sering dikaitkan dengan masalah pada kesehatan salah satunya pada organ hepar. Tujuan Penelitian ini untuk mengetahui pengaruh paparan komponen bensin atau metabolitnya terhadap kerusakan struktur hepar tikus. Penelitian ini menggunakan metode Scoping Review untuk menganalisis, mengidentifikasi dan mengevaluasi artikel ilmiah yang sesuai dengan kriteria inklusi maupun ekslusi. Penelitian ini melakukan skrining menggunakan kriteria kelayakan (Eligibility Criteria) dengan population yang digunakan tikus, intervention paparan bensin, comparison tikus normal yang tidak dipaparkan bensin dan outcome kerusakan struktur hepar tikus sehingga yang diperoleh yaitu 936 artikel dan terdapat sembilan artikel yang dapat memenuhi kelayakan. Hasil penelitian ini menunjukan bahwa terdapat perubahan pada struktur sel hepar tikus yang ditandai dengan adanya nekrosis, inflamasi, dan membesarnya vena portal hepatika. Simpulan penelitian ini menunjukkan terdapat pengaruh paparan komponen bensin atau metabolitnya terhadap kerusakan struktur hepar tikus dengan menunjukkan adanya perubahan degeneratif, nekrosis, melebarnya vena portal hepatika.
Kata Kunci: Bensin, Kerusakan struktur Hepar, Tikus
Keywords
Full Text:
PDFReferences
Referensi
Winarno J. Studi Emisi Gas Buang Kendaraan Bermesin Bensin Pada Berbagai Merk Kendaraan Dan Tahun Pembuatan. J Tek. 2014;
Febrian N W, Rahardjo M, Nurjazuli. Analisis Risiko Kesehatan Lingkungan Akibat Paparan Benzene Melalui Inhalasi Pada Awak Mobil Tangki di PT Pertamina Patra Niaga. J Kesehat Masy. 2019.
A.D S, Restadiamawati R. Pengaruh Paparan Uap Bensin Terhadap Frekuensi Pembentukan Mikronukleus Mukosa Bukal pada Penjual Bensin Eceran. J Kedokt Diponegoro. 2012.
Mulyono S, Gunawan G, Maryanti B. Pengaruh Penggunaan dan Perhitungan Efisiensi Bahan Bakar Premium dan Pertamax Terhadap Unjuk Kerja Motor Bakar Bensin. JTT (Jurnal Teknol Terpadu). 2014.
Ekpenyong CE, Asuquo AE. Recent advantage in occupational and environtmental health hazards of workers exposed to gasoline compounds International Journal of Occupational Medicine and Environmental Health 2017;30(1):1–26
Icha P. Gambaran Faktor Yang Mempengaruhi Ketidakpatuhan Menggunakan APD Di SPBU ‘ X ‘ Surabaya Icha Pamelia Description Of Factors That Influence Non-compliance Of PPE Usage At Gas Station ‘ X ‘ In Surabaya. 2019;3(1).
Arief Tasleem, heavy metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. International Journal of Molecular Sciences 2015;10(26):
Litalien D, Guay F, Geoffrion S, Giguère C-É, Fortin M, Fortin C, et al. Bifurcations. 2010;45(1):1–19.
Abdrabouh AE. Liver disorders related to exposure to gasoline fumes in male rats and role of fenugreek seed supplementation. Environ Sci Pollut Res. 2019 Feb.
Gasoline A, Minyak BB, Bbm P, Turbine A, Minyak BB, Jenis B, et al. Hak Cipta © 2019 Badan Pengatur Hilir Minyak Dan Gas Bumi. 2019;(45).
Mohammed BJ. A search for the effect of gasoline exposure and viability, apoptosis, necrosis of peripheral blood mononuclear cells and polymorphisms in fas -FasL genes in blood of gasoline stations Iraqi workers. Biomed. 2017;37(3):375–81.
Keselamatan B, Masyarakat FK. Hubungan Paparan Kadar Toluene Di Udara Dengan Fungsi Ginjal Pada Pekerja Bagian Pengecatan Perusahaan Karoseri X Magelang. J Kesehat Masy. 2016;3(1):437–44.
Irawati Y. Analisis Resiko Kesehatan Pajanan Xylene Pada Pekerja Bengkel Sepatu ‘X’ Di Kawasan Perkampungan Industri Kecil (Pik) Pulogadung Jakarta Timur 2010.
Drake RL, Vogl W, Mitchell AWM, Vogl AW. Gray’s Basic Anatomy. Zhurnal Eksperimental’noi i Teoreticheskoi Fiziki. 2012.
Meschel AL. Histologi Dasar Junqueira Teks & Atlas. Vol. 12, Histologi Dasar Junqueira Teks & Atlas. 2012. 396–398 p.
Hall J, Guyton C. Buku Ajar Fisiologi Kedokteran. 12th ed. Philadelphia: Elsevier; 2011.
Vinay Kumar, Abul K. Abbas, Jon C. Aster SLR. Buku Ajar Patologi Robbins Edisi 9. Elsevier. 2013.
Metwally ESA, Negm FA, El-din RAS, Nabil EM. Anatomical and Histological Study of the Effect of Lead on Hepatocytes of Albino Rats. nternational Journal of Biomedical Materials Research.
; 3(4):34-45.
Owagboriay, Ojo F, Adewunmi G. Assessment Of Liver Dysfunction in Albino Rats Exposed to Gasoline Fume. African Journal of Science & Nature. 2017;4:12-19.
Jarrar BM, Taib NT. Histological and histochemical alterations in the liver induced by lead chronic toxicity. Saudi J of Bio Sci. 2012 Jan 5;19:203–210.
Offor SJ, Mbagwu HOC, Orisakwe OE. Lead induced hepato-renal damage in male albino rats and effects of activated charcoal. Front. Pharmacol. 2017 Mar 14;8(107):1-10.
Abdrabouh AE. Liver disorders related to exposure to gasoline fumes in male rats and role of fenugreek seed supplementation. Environ Sci Pollut Res. 2019 Feb 4.
Dewanjee S, Sahu R, Karmakar S, Gangopadhyay M. Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves. Food and Chemical Toxicology. 2013 Jan 2;55:78–91.
DOI: http://dx.doi.org/10.29313/kedokteran.v7i1.26622
