Hubungan Lamanya Kemoterapi dengan Risiko Neuropati Perifer pada Pasien Kanker Payudara di RSUD Al-Ihsan Bandung

Dewi Mulyani Rahayu, Yusuf Heriady, Alya Tursina

Abstract


Abstract. Breast cancer is the leading cause of death among women. In Indonesia there are still many women who suffer from breast cancer and continue to increase every year. Treatment of breast cancer such as chemotherapy that can trigger the occurrence of peripheral neuropathy. The purpose of this study was to determine the relationship between the chemotherapy period and age to the risk of peripheral neuropathy. This study is a analytic study with cross sectional design. Data obtained from questionnaires with the number of respondents 80 people. The data were processed using chi-square test. The results of the study showed that the  age category of chemotherapy ≥6 months that experienced peripheral neuropathy as many as 23 people while for chemotherapy period <6 months as many as 19 people. The result of statistic test showed no correlation between chemotherapy period with P-value 0,822 (P-value >0,05) . It occurs because many factors that influence it include age factors, clinical stages, general status / physical resistance, nutritional status, large doses, and the chemotherapy drugs period, thus providing the effects of different side effects.

Keywords: Age, Breast Cancer, Duration of Chemotherapy, Peripheral neuropathy

 

Abstrak. Kanker payudara merupakan penyebab kematian utama pada kalangan wanita. Di Indonesia masih banyak wanita yang mengidap penyakit kanker payudara dan terus meningkat setiap tahunnya. Pengobatan dari penyakit kanker payudara diantaranya adalah kemoterapi yang dapat memicu timbulnya neuropati perifer.Tujuan penelitian ini adalah untuk mengetahui hubungan antara lama kemoterapi dan usia terhadap risiko neuropati perifer. Penelitian ini merupakan studi analitik dengan desain potong lintang. Data diperoleh dari kuesioner dengan jumlah responden 80 orang. Data diolah menggunakan uji hubungan Chi-square. Hasil penelitian menunjukan bahwa kategori lama kemoterapi ≥6 bulan yang mengalami neuropati perifer sebanyak 23 orang sedangkan lama kemoterapi <6 bulan  sebanyak 19 orang . Hasil uji statistik menunjukan tidak terdapat hubungan antara lama kemoterapi dengan nilai P-value sebesar 0,822 (P-value >0,05). Hal demikian terjadi karena banyak faktor yang mempengaruhinya antara lain  faktor usia, faktor stadium klinis, status umum/ketahanan fisik, status gizi, besar dosis, dan durasi pemberian dari obat kemoterapi, sehingga memberikan dampak efek samping yang berbeda-beda.

Kata kunci: Usia, Kanker Payudara, Lama Kemoterapi, Neuropati Perifer  


Keywords


Usia, Kanker Payudara, Lama Kemoterapi, Neuropati Perifer

Full Text:

PDF

References


America Cancer Asociety. Chemotherapy for Breast Cancer. America Cancer Asociety. 2017 [diunduh 2018 Feb 1].

Aninditha T, Wiratman W. Buku Ajar Neurologi. 1st ed. Azmi IN, Mumfaridah, editors. Jakarta: Departemen Neurologi Fakultas Kedokteran Universitas Indonesia; 2017. 641-660-676 p

Bao T, Basal C, Seluzicki C, Li SQ, Seidman AD, Mao JJ. Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk. Breast Cancer Res Treat. 2016 Sep;159(2):327–33. [diunduh 2018 Feb 20].

Faisel CTW. Gambaran Efek Samping Kemoterapi Berbasis Antrasiklin Pada Pasien Kanker Payudara Di Rsud Dokter Soedarso.2013;1(1):4-6.

Kautio A. Chemotherapy-induced neuropathy : prevention and treatment. 2012. 18-24 p.

Kementrian Kesehatan RI. kanker payudara. Oktober 2016; tersedia dari:http://www.depkes.go.id/resources/download/pusdatin/infodatin/InfoDatin Bulan Peduli Kanker Payudara_2016. [diunduh 2018 Jan 30]

Miltenburg NC, Boogerd W. Chemotherapy-induced neuropathy : A comprehensive survey. Cancer Treat Rev.2014.04.004

Perbowo Primadona. Perbandingan Kejadian Neutropenia dan Neuropati Perifer Akibat Kemoterapi Adjuvan Paclitaxel-Carboplatin antara Paclitaxel Infus 3 Jam dengan Paclitaxel Infus 24 Jam pada Penderita Kanker Ovarium Stadium I-IV. Obstet Ginekol. 2008;16:108–116. [diunduh 2018 Jul 22].

Society A cancer. Peripheral Neuropathy Caused by Chemotherapy What is chemotherapy-induced peripheral neuropathy. 2015;2–3.

Starobova H, Vetter I. Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy. Front Mol Neurosci. 2017 Mei 31;10:4–7. [diunduh 2018 Feb 20].




DOI: http://dx.doi.org/10.29313/kedokteran.v0i0.13332

Flag Counter    Â