The Effect Of Ethanol Extract Of Leaves Of Soursop leaves (Annona Muricata L.) As An Antidepressant on Male Mice Of Swiss Webster

Silvia Praja, Umi Yuniarni, Sri Peni Fitrianingsih

Abstract


Soursop leaves have been traditionally used by many people in treating various diseases such as kidney problem, hypertension, anticonvulsants, anxiety, sedative and others. This research aims is to assess effect of ethanol extract of soursop leaves (Annona muricata L.) as an antidepressant on male mice of swiss webster. The antidepressant testing method used is Forced Swimming Test (FST). The test animal are divided into several groups, control group is given CMC Na 0,5%, comparison group is given amitriptyline 3,2 mg/kg bb, EEDS test group dose 1 125 mg/kg bb, EEDS test group dose 2 250 mg/kg bb, and EEDS test group dose 3 500 mg/kg bb. Induction of depression performed using FST to give effect of acute depression. Antidepressants analysis is observed from number of imobility time. The result shows that there significant differences (p<0,05) between control group, and other 4 groups. Effective dose of antidepressant effect is a dose of 250 mg/kg.

Keywords


Antidepressant, Forced Swimming Test, Leaves of Soursop (Annona muricata L.), Acute depression

References


Arthur, F.K.N., Woode, E., Terlabi, E.O. and Larbie, C. (2011). Evaluation of acute and subchronic toxicity of

Annona Muricata (Linn.) aqueous extract in animals, European Journal of Experimental Biology, Vol. 1, No. 4. hal 116.

Bruton, L., Parker, K., Blumenthal, D., Buxton, L. (2010). Goodman and Gilman, Manual Farmakologi dan Terapi. EGC, Jakarta.

Dahlan, M.S. (2009). Statistik Untuk Kedokteran dan Kesehatan,

Salemba Medika, Jakarta.Departemen Kesehatan RI. (1995). Materia Medika Indonesia.

Jilid V. Direktorat jendral pengawasan obat dan makanan, Jakarta.

Gould T.D., Can, A., Dao, D.T., Arad, M., Terillion, C.E., Piantadosi S.C. (2012). The Mouse Forced Swimming Test, Journal of Visualized Experiments, 29 Jan, Vol 59. hal 1-5.

Katzung, B. G. (2010). Farmakologi Dasar dan Klinik Edisi 10, EGC, Jakarta.

Pinto A.C. de Q., Corderio, M.C.R., Andrade, S.R.M.De., Ferreira, F.R., Filgueiras,

H.A. de C., Alves, R.E., and Kinpara D.I. (2005). Annona Species, International Centre for Underutilized Crops, University of Southampton, United Kingdom.

Sherwood, Lauralee. (2011). Fisiologi Manusia : dari Sel ke Sistem, EGC, Jakarta.

Sousa, O.V., Vieira, G.D., Pinho, J., Yamamoto, P.H., Alves, M.S.(2010). Anti-Inflamatory Activities of the Ethanol

Extract of Annona muricata Linn Leave in Animal Models, International Journal of Molecular Sciences, 6 May, Vol. 11, No. 5. hal 1.

Tjay, T.H. dan Rahardja, K . (2007). Obat-obat Penting, Khasiat, Penggunaan dan Efek-efek Sampingnya, Edisi Keenam, PT Elex Media Komputindo, Jakarta. hal 462-467.

Vázqueza, M.M., Reyes, E.R., Escalona, A.G.A., Velazquez, L.I., Mota, M.L., Moreno, J., and Heinze, G. (2012). Antidepressant-like Effects of an Alkaloid Extract of TheAerial Parts of Annona Cherimolia in Mice, Journal of Ethnopharmacology, 2 June, Vol. 139, No. 1




DOI: http://dx.doi.org/10.29313/.v0i0.2905

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