Formulasi Suppositoria yang Mengandung Kompleks Inklusi Ibuprofen – Β Siklodekstrin

Mohammad Ikbal Septian, Fitrianti Darusman, Embit Kartadarma

Abstract


Abstract: Based on the Biopharmaceutics Classification System (BCS), Ibuprofen is classified as class II BCS because of its low solubility and high permeability. Inclusion complex is one method to increase drug solubility. In addition to the method of increasing solubility, the selection of dosage forms and route of administration has a large role in the success of therapy because it can affect the onset of action of the drug as well as the resulting side effects. Rectal administration of ibuprofen with suppositories can have a faster temperature reduction effect than oral preparations. Making inclusion complex is done by coprecipitation method. Tests carried out include dissolution test, melting time, suppository weight uniformity and homogenity test. Dissolution test showed that the amount of ibuprofen dissolved for 120 minutes and dissolution efficiency at 120 minutes increased on suppositories with complex inclusion systems. From the results of the study it can be concluded that the use of β cyclodextrin as a complexing compound in the inclusion complex can increase dissolution in cacao fat-based suppositories. The optimum inclusion formula in increasing dissolution is in the ratio of ibuprofen and β cyclodextrin to 1: 2.

 

Keywords: Ibuprofen, Inclusion Complex, β Siklodekstrin, Suppositories

 

Abstrak: Berdasarkan klasifikasi biofarmasetika atau Biopharmaceutics Classification System (BCS), Ibuprofen tergolong dalam BCS kelas II karena kelarutannya yang rendah dan permeabilitas yang tinggi. Kompleks inklusi merupakan salah satu metode untuk meningkatkan kelarutan obat. Selain metode peningkatan kelarutan, pemilihan bentuk sediaan dan rute pemberian memiliki peran yang besar dalam keberhasilan terapi karena dapat mempengaruhi onset kerja obat serta efek samping yang dihasilkan. Pemberian ibuprofen melalui rektal dengan sediaan supositoria dapat memberikan efek penurunan suhu yang lebih cepat dibandingkan sediaan oral. Pembuatan kompleks inklusi dilakukan dengan metode kopresipitasi. Pengujian yang dilakukan meliputi uji disolusi, waktu leleh , keseragaman bobot suppositoria dan uji homogenitas. Uji disolusi menunjukkan bahwa jumlah ibuprofen yang terdisolusi selama 120 menit dan effisiensi disolusi pada menit ke 120 meningkat pada suppositoria dengan system kompleks inklusi. Dari hasil penelitian dapat disimpulkan bahwa penggunaan β Siklodekstrin sebagai senyawa pengompleks dalam kompleks inklusi dapat meningkatkan disolusi pada sediaan suppositoria berbasis lemak coklat. Formula kompleks inklusi yang optimum dalam meningkatkan disolusi adalah pada perbandingan ibuprofen dan β Siklodekstrin sebesar 1:2.

Kata kunci : Ibuprofen, Kompleks Inklusi, β Siklodekstrin, Suppositoria


Keywords


Ibuprofen, Inclusion Complex, β Siklodekstrin, Suppositories

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References


Allen, L.V. dan Ansel, H.C. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 10th ed, Lippincott Williams & Wilkins, United States; 2014.

Challa, R., Ahuja, A., Al, J., Khar, R.K. (2005). Cyclodextrin in Drug Delivery, An Updated Review. AAPS PharmSciTech, Volume. 6, Issue. 2, Article 43.

Chaudhary, A., Nagaich, U., Gulati, N., Sharma, V., K., & Khosa, R., L. (2012). Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research, 2, (1), 32-6.Nayak BS, Sandiford S, Maxwell A. Evaluation of the wound-healing activity of ethanolic extract of Morinda citrifolia L. leaf . (2009);6(3):351–6.

Handayani, S., Hadinegoro, S.R., Sastroasmoro, S. The Efficacy of Suppository Versus Oral Ibuprofen for Reducing Fever in Children, Paediatrica Indonesiana. 2005; 45 (9-10): 211-216.

Lindenberg, M., Kopp, S. dan Dressman, J.B. Classification of Orally Administered Drugs on the World Health Organization Model List of Essential Medicines According to the Biopharmaceutics Classification System. European Journal of Pharmaceutics and Biopharmaceutics, 2004; 58: 265– 278.

Loftsson, T., & Brewster, M. E. (1996). Pharmaceutical applications of βsiklodekstrin, drug solubilization and stabilization. J Pharm Sci, 85, (10), 1017-1024.

Sutriyo, Rachmat, H. & Rosalina, M. Pengembangan Sediaan dengan Pelepasan Dimodifikasi Mengandung Furosemid sebagai Model Zat Aktif Menggunakan Sistem Mukoadhesif. Majalah Ilmu Kefarmasian, 2008; Vol. V, No.1, April. pp.1-8

Sweetman, Sean C. (2009). Martindale The Complete Drug Reference 36th Ed, Pharmaceutical Press, USA.




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