The Effectiveness of Elephant Ginger Rhizome (Zingiber officinale Rosc.) Water Extract to Decrease Total Blood Cholesterol Level on Mice Induced Propylthiouracil

Eneng Utari Vitaloka, Arief Budi Yulianti, Eva Rianti Indrasari

Abstract


Hypercholesterolemia is a major risk factor for coronary heart disease and stroke.  Active compounds contained in ginger are gingerol, shogaol and niacin (B3) can potentially reduce total blood cholesterol levels. The purpose of this study is to know the effectiveness  rhizome of elephant ginger (Zingiber officinale Rosc.) water extract to decrease total cholesterol blood  levels in mice feed high-fat and induced propylthiouracil. The methode of this study was experimental with 30 male mice DDY strain fed high fat and induced propylthouracil 0.01% for 7 days in group II-VI. Elephant ginger rhizome warter extract was given at doses 28; 56; and 112 mg/kg weight with positive control of simvastatin 0,026 mg/kg weight. The result were analyzed by One Way ANOVA Test and  followed by Post-Hoc test. The Result: decrease of average total cholesterol levels of group I-VI blood respectively: 1.40; 22.00; 65,60; 62,20; 62,20 and 58,60 mg/dL (p = 0,035). The treat elephant ginger rhizome water extract doses 28 mg/kg weight and 56mg/kg weight have similarity of simvastain effectivity doses 0,026 mg/kg weight, but in doses 112 mg/kg weight have least  than effectivity so  might be its doses optimum not clearly. Conclusion: elephant ginger rhizome water extract can decrease total cholesterol of mice blood induced propylthiouracil

Keywords


Elephant ginger rhizome water extract, cholesterol, propylthiouracil, simvastatin

References


World Health Organization. Global status report on noncommunicable diseases 2010. World Health. 2010:25.

Kementerian kesehatan RI. Situasi kesehatan jantung di Indonesia 2014. Jakarta. 2014:2.

Arsana PM, Rosandi R, Manaf A, et al. Panduan Pengelolaan Dislipidemia di Indonesia. PB Perkeni. 2015;1:25-27.

Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Well PA. Harper’s illustrated biochemisty. 29th edition. United State: McGraw-Hill Companies, Inc.2012.

Stone NJ, Robinson JG, Lichtenstein AH, et al. Guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American college of cardiology/American heart association task force on practice guidelines. Journal of the American College of Cardiology. 2014;63(25 part B):2889-2934.

National institute of health. NCEP cholesterol guidelines. National Cholesterol Education Program ATP III. 2001;329(3):925-929.

Peraturan menteri kesehatan RI No 6 tahun 2016. Formularium obat herbal asli Indonesia. 2016:6-11.

Kania A, Kharisma Y. Dewi M. Bekatul (Oryza sativa L.) menghambat peningkatan kadar kolesterol darah. Global Medical and Health Communication. 2014;2:36-40.

Karimah F, Achmad S, Suganda R. Efek jus buah naga super merah (Hylocereus costaricensis) dan simvastatin terhadap kadar kolesterol total darah dan bobot badan tikus jantan galur wistar hiperkolesterolemia. Global Medical and Health Communication. 2014;2:81-83.

Hemani. Pengembangan biofarmaka sebagai obat herbal untuk kesehatan. Teknologi pascapanen tanaman obat. 2011;7:34-36.

Mosovska S, Novakova D, Kalinak M. Antioxidant activity of ginger extract and identification of its active components. Acta Chimica slovaca. 2015;8(2):115-119.

Elrokh ESM, Yassin NAZ, El-Shenawy SMA, Ibrahim BMM. Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale Rosc.) in rats. Inflammopharmacology. 2010;18(6):309-315.

Supriadi, M.Yusron, Wahyuno D. Bunga rampai jahe (Zingiber Officinale Rosc.). (Miftahudin aeafiana, ed.). Bogor: Supriadi, M. Yusron, Dono W; 2011:8-9.

Sunaryo H, Rahmania RA. Aktivitas antioksidan kombinasi ekstrakjahe gajah (Zingiber officinale Rosc.) dan zink berdasarkan pengukuran MDA, SOD dan Katalase pada mencit hiperkolesterolemia dan hiperglikemia dengan penginduksi streptozotosin antioxidant activity of combination. Jurnal ilmu kefarmasian Indonesia. 2015;13(2):187-193.

Nammi S, Sreemantula S, Roufogalis BD. Protective effects of ethanolic extract of zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic and Clinical Pharmacology and Toxicology. 2009;104(5):366-373.

Qudoos Abdul, Niaz Khalid, Hakro Shhina MS. Research article single blind placebo-controlled study on comparision of effects of zingiber officinale before and after treatment in hyperlipidemia. Journal drug Delivery and Therapeutic. 2016;6(3):90-92.

Septiana A, Muchtadi D, Zakaria F. Aktivitas antioksidan ekstrak diklorometana dan air jahe (Zingiber officinale Roscoe) pada asam linoleat. Jurnal teknol dan industri pangan. 2002;13(2):105-107.

Sahoo DB, Parijatham DBO. Effects of hypothyroidism on total cholesterol, triglycerides and LDL. Scholars Journal of Applied Medical Sciences 2016;4(6):2056-2058.




Flag Counter