Clozapine Effektif pada Pasien Skizofrenia yang Resisten terhadap Pengobatan

Natasha Syifa Rachman, Dede Setiapriagung, Siti Annisa Devi Trusda


Abstract. Schizophrenia is a neuropsychiatric disorder with a high morbidity rate. One of the therapies to treat schizophrenic patients is to use antipsychotics such as typical and atypical drugs. Typical antipsychotics are the first line of treatment for schizophrenia but recently resistance is often developed, so that therapy is switched to atypical antipsychotics. Clozapine is the most commonly used atypical antipsychotic. The aim of this study was to determine the effectiveness of clozapine in schizophrenic patients who were resistant to other antipsychotics. . The method used in this study is a scoping review, with research articles from international journals that meet the inclusion and exclusion criteria. This article was then selected using the PRISMA diagram by considering Population (schizophrenic patients), Intervention (giving clozapine), Comparison (placebo or other antipsychotic), Outcome (reduction in psychotic symptoms), Study (RCT, clinical trial, case report, and meta analysis) . The results of this study indicate that clozapine is one of the most effective atypical antipsychotics compared to other antipsychotic drugs to treat patients suffering from schizophrenia, especially for schizophrenic patients who are resistant to other antipsychotic treatments.

Keywords : Atypical Antipsychotic, Clozapine, Schizophrenia, Typical Antipsychotic, resistant

Abstrak. Skizofrenia merupakan gangguan neuropsikiatik dengan angka morbiditas yang masih tinggi. Salah satu terapi untuk menangani pasien skizofrenia adalah dengan menggunakan antipsikotik berupa tipikal dan atipikal. Antipsikotik tipikal menjadi lini pertama pengobatan skizofrenia. Dewasa ini berkembang penelitian bahwa sering terjadi resistensi terhadap antipsikotik tipikal, sehingga terapi beralih ke antipsikotik atipikal. Clozapine merupakan antipsikotik atipikal yang paling sering digunakan. Tujuan penelitian ini  adalah mengetahui efektifitas clozapine terhadap pasien skizofrenia yang resisten terhadap antipsikotik lain.  Metoda yang digunakan dalam penelitian ini adalah scoping review, dengan bahan penelitian artikel dari jurnal internasional yang memenuhi kriteria inklusi dan eksklusi. Artikel ini kemudian diseleksi menggunakan diagram PRISMA dengan mempertimbangkan Population (pasien skizofrenia), Intervention (pemberian clozapine), Comparison (plasebo atau antipsikotik lain), Outcome (penurunan gejala psikotik), Study (RCT, clinical trial, case report, dan meta analysis ). Hasil penelitian ini menunjukan bahwa clozapine merupakan salah satu antipsikotik atipikal yang paling efektif dibandingkan dengan obat antipsikotik lainnya untuk mengobati pasien yang menderita skizofrenia, khususnya untuk pasien skizofrenia yang resisten terhadap pengobatan antipsikotik lain.

Kata Kunci : Antipsikotik Atipikal, Antipsikotik Tipikal, Clozapine, Skizofrenia, Resisten


Antipsikotik Atipikal, Antipsikotik Tipikal, Clozapine, Skizofrenia, Resisten


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