Kepatuhan Terapi Kelasi Besi Berdasarkan Kadar Feritin pada Penderita Thalassemia di Rumah Sakit Syamsudin Kota Sukabumi

Refita Trianisya, Ieva Baniasih Akbar, Ismawati Ismawati

Abstract


Abstract. Thalassemia is a blood disorder that results from decreased or lost synthesis of one or more globin chains. Transfusion is indicated in thalassemia patients with an Hb level 7 g / DL. Then to prevent the presence of iron deposits in the body due to repeated transfusions, chelation therapy is needed to reduce the morbidity and mortality rates in thalassemia patients. Several studies found that patients with thalassemia who were adherent to iron chelation therapy had ferritin levels 2500μg / L. The purpose of this study was to describe the adherence of iron chelation therapy in thalassemia patients at Syamsudin SH Hospital. This research used quantitative descriptive method with cross sectional research design. The study population was 148 thalassemia patients based on medical record data with the sampling technique, namely total sampling. This study found that the sex of female 75 patients (50.7%), male gender 73 patients (49.3%), ferritin levels ≤ 2500μg / L (36.48%), ferritin levels> 2500μg / L (63.52%) with a mean ferritin level in all thalassemia patients of 4.607.79

Keywords : Chelation Therapy, Ferritin Levels µg / L. The conclusion of this study that most thalassemia patients were not adherent to taking chelation therapy.

Abstrak. Thalassemia adalah kelainan darah yang terjadi akibat penurunan atau hilangnya sintesis dari satu atau lebih rantai globin. Transfusi diindikasikan pada pasien thalassemia dengan kadar Hb < 7 g/dL. Kemudian untuk mencegah adanya timbunan besi dalam tubuh akibat transfusi berulang dibutuhkan terapi kelasi sehingga mengurangi tingkat morbiditas dan mortalitas pada pasien thalassemia. Beberapa penelitian menemukan bahwa penderita thalassemia yang patuh  dalam menjalankan terapi kelasi besi memiliki kadar feritin <2500μg/L. Tujuan penelitian ini untuk mengetahui gambaran kepatuhan terapi kelasi besi pada pasien thalassemia di RS Syamsudin SH. Penelitian ini menggunakan metode deskriptif kuantitatif dengan desain penelitian cross sectional. Populasi penelitian ini 148 pasien thalassemia berdasarkan data rekam medis dengan teknik pengambilan sampel yaitu total sampling. Penelitian ini mendapatkan hasil jenis kelamin perempuan 75 pasien (50,7%), jenis kelamin laki-laki 73 pasien (49,3%), kadar feritin ≤ 2500μg/L (36,48%), kadar feritin >2500μg/L (63,52%) dengan rerata kadar feritin pada seluruh pasien thalassemia sebesar 4.607,79μg/L. Kesimpulan dari penelitian ini sebagian besar pasien thalassemia tidak patuh dalam mengonsumsi terapi kelasi.

Kata Kunci : Kadar Feritin, Terapi Kelasi


Keywords


Kadar Feritin, Terapi Kelasi

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DOI: http://dx.doi.org/10.29313/kedokteran.v7i1.26825

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