Hubungan Antara Kontrol Glikemik (HbA1c), Durasi Penyakit, dan Profil Lipid dan Kejadian Neuropati Diabetik Pada Pasien Diabetes Melitus Tipe II : Scoping Review

Salma Kautsar Rachman, Eka Hendryanny, Tryando Bhatara

Abstract


Abstract. Diabetes is a chronic metabolic disorder which is a disease with a high prevalence and incidence every year throughout the world, including in Indonesia. This disease becomes a more serious problem when there are complications, one of which is diabetic neuropathy. Diabetic neuropathy can occur due to various factors, including poor glycemic control, duration of diabetes, and abnormal levels of lipid profiles. This study aims to determine the relationship between HbA1c control, duration of diabetes, and lipid profile with the incidence of diabetic neuropathy. The scoping review systematic search used 12 research reports obtained from several journal databases, such PubMed and Science Direct lasts from October to November 2020. The results of the articles is there were 6 research reports that reported an association between glycemic control and the incidence of diabetic neuropathy. There were 5 research reports that reported an association between the duration of suffering from diabetes and the incidence of diabetic neuropathy. There were 4 research reports that reported an association between lipid profiles and the incidence of diabetic neuropathy. The conclusions of the 12 research reports are there is an association of glycemic control, duration of diabetes, and lipid profile with the incidence of diabetic neuropathy.

Key words: diabetic neuropathy; duration of illness; HbA1c; lipid profile; type II diabetes mellitus

Abstrak. Diabetes merupakan penyakit gangguan metabolik kronik yang menjadi salah satu penyakit dengan prevalensi dan insidensi tinggi setiap tahunnya di seluruh dunia, termasuk di Indonesia. Penyakit ini menjadi masalah yang lebih serius ketika terjadi komplikasi mikroangiopati dan makroangiopati, salah satunya neuropati diabetik. Neuropati diabetik dapat terjadi karena berbagai faktor, antara lain kontrol glikemik yang buruk, durasi penyakit, dan kadar profil lipid yang abnormal. Penelitian bertujuan untuk mengetahui hubungan kontrol HbA1c, durasi menderita diabetes, dan profil lipid dengan kejadian neuropati diabetik. Pencarian sistematis scoping review menggunakan 12 laporan penelitian yang diperoleh dari beberapa database jurnal, yaitu PubMed dan Science Direct yang dilakukan pada bulan Oktober-Desember 2020. Hasil yang didapatkan adalah didapatkan dari 6 laporan penelitian yang melaporkan adanya hubungan antara HbA1c dengan kejadian neuropati diabetik. Didapatkan 5 laporan penelitian yang melaporkan adanya hubungan antara durasi menderita diabetes dengan kejadian neuropati diabetik. Didapatkan 4 laporan penelitian yang melaporkan adanya hubungan antara profil lipid dengan kejadian neuropati diabetik. Kesimpulan dari 12 laporan penelitian tersebut adalah terdapat hubungan kontrol glikemik, durasi menderita diabetes, dan profil lipid dengan kejadian neuropati diabetik.

Kata kunci: neuropati diabetes; durasi penyakit; HbA1c; profil lipid; diabetes mellitus tipe II


Keywords


neuropati diabetes; durasi penyakit; HbA1c; profil lipid; diabetes mellitus tipe II

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DOI: http://dx.doi.org/10.29313/kedokteran.v7i1.26486

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