Scoping Review: Pengaruh Terapi TURP terhadap Benign Prostatic Hyperplasia pada Lansia

Dito Dewantoro Satriawan, Diana Wijayanti, Meta Maulida Damayanti

Abstract


Abstract. Benign prostatic hyperplasia (BPH) is a histopathological term, which is hyperplasia of stromal cells and epithelial cells of the prostate gland, and is benign. The prevalence of BPH occurs in about 70% in men over the age of 60. The goal of therapy in BPH patients is to improve the patient's quality of life. One of the treatment options for BPH is the Transurethral Resection of Prostate (TURP) which is the most widely used method to treat an enlarged prostate. The purpose of this study was to describe the effect of TURP therapy on BPH in the elderly. This research is a Scoping Review, which is taken from the PubMed, Springer Link, and Science Direct databases using the original research articles (observational) method. This study was assessed by PICOS to be determined as eligible criteria on the appropriate prism flow chart, namely population (BPH patients, the elderly), intervention (TURP therapy), comparison (other therapies), 10,025 articles of outcome (recovery of BPH patients), and test results. based on PICOS as many as 10 articles. The results of the analysis and review of these 10 articles are: TURP therapy has many functions and benefits for improving the patient's condition. These indicators can be assessed from the decreased risk of bleeding, time of operation, time of bladder irrigation, duration of catheterization, duration of hospitalization, improvement in IPSS, QoL, Qmax, PVR, serum Na +, serum K +, levels of hematocrit, volume of irrigation fluid, hemoglobin levels, serum creatinine, baseline prostate volume, IIEF-5, CTCAE, SHIM, MSHQ-EjD, and ISI. Patients with BPH may also be at risk of intraoperative or postoperative complications. The conclusion of this study shows that the effect of TURP therapy on BPH in the elderly has good, efficient and effective results.

Keywords: Benign prostatic hyperplasia, the elderly, TURP therapy

Abstrak. Benign Prostatic Hyperplasia (BPH) merupakan istilah histopatologis, yaitu adanya hiperplasia sel stroma dan sel epitel kelenjar prostat,dan bersifat jinak. Prevalensi BPH terjadi sekitar 70% pada pria di atas usia 60 tahun. Tujuan Terapi pada pasien BPH adalah untuk memperbaiki kualitas hidup pasien. Salah satu pilihan terapi untuk BPH yaitu Transurethral Resection of Prostate (TURP) yang merupakan metode paling banyak digunakan untuk mengatasi pembesaran prostat. Tujuan penelitian ini adalah untuk melihat gambaran pengaruh terapi TURP terhadap BPH pada lansia. Penelitian ini merupakan Scoping Review, yang diambil dari database PubMed, Springer Link, dan Science Direct dengan metode original research articles (observasional). Penelitian ini dinilai secara PICOS untuk ditentukan sebagai kriteria eligible pada prisma flow chart yang sesuai yaitu population (pasien BPH, lansia), intervention (terapi TURP), comparison (terapi lain), outcome (kesembuhan pasien BPH) terdapat 10.025 artikel, dan hasil uji berdasarkan PICOS sebanyak 10 artikel. Hasil analisis dan review dari 10 artikel ini yaitu: terapi TURP memiliki banyak fungsi serta manfaat untuk perbaikan kondisi pasien. Indikator tersebut dapat dinilai dari menurunnya risiko perdarahan, waktu operasi, waktu irigasi kandung kemih, durasi kateterisasi, durasi rawat inap, perbaikan pada IPSS, QoL, Qmax, PVR, serum Na+, serum K+, kadar hematokrit, volume cairan irigasi, kadar hemoglobin, serum kreatinin, volume prostat dasar, IIEF-5, CTCAE, SHIM, MSHQ-EjD, dan ISI. Pasien BPH juga dapat mengalami risiko komplikasi intraoperatif ataupun pasca operatif. Kesimpulan penelitian ini menunjukkan bahwa pengaruh terapi TURP terhadap BPH pada lansia mempunyai hasil yang cukup baik, efisien dan efektif.

Kata kunci: Benign Prostatic Hyperplasia, lansia, terapi TURP


Keywords


Benign Prostatic Hyperplasia, lansia, terapi TURP

References


Parsons JK. Benign prostatic hyperplasia and male lower urinary tract symptoms: epidemiology and risk factors. Curr Bladder Dysfunct Rep. 2010;5:212-18.

Chan SW. Pathology and medical therapy of benign prostatic hyperplasia. Medical Bulletin. 2011:16(6).4-8.

Mochtar CA, Umbas R, Soebadi DM, Rasyid N, Noegroho BS, Poernomo BB, et al. Panduan Penatalaksanaan Klinis Pembesaran Prostat Jinak (Benign Prostatic Hyperplasia/BPH). Ikatan Ahli Urologi Indonesia. 2015.

Gravas S, Bachmann A, Descazeaud A, Drake M, Gratzke C, Madersbacher S, Mamoulakis C, et al. Guidelines on the management of non-neurogenic male lower urinary tract symptoms (LUTS), incl. benign prostatic obstruction (BPO). European Association of Urology. 2014.

Otto B, Barbieri C, Lee R, Te AE, Kaplan SA, Robinson B, et al. Incidental prostate cancer in transurethral resection of the prostate specimens in the modern era. Adv Urol. 2014;(2014):627290.

Zhang J, Wang X, Zhang Y, Shi C, Tu M, Shi G. 1470 nm Diode Laser Enucleation vs Plasmakinetic Resection of the Prostate for Benign Prostatic Hyperplasia: A Randomized Study. J Endourol. 2019 Mar;33(3):211-217.

Elsakka AM, Eltatawy HH, Almekaty KH, Ramadan AR, Gameel TA, Farahat Y. A prospective randomised controlled study comparing bipolar plasma vaporisation of the prostate to monopolar transurethral resection of the prostate. Arab J Urol. 2016 Nov;14(4):280-286.

Kasivisvanathan V, Hussain M. Aquablation versus transurethral resection of the prostate: 1 year United States - cohort outcomes. Can J Urol. 2018 Jun;25(3):9317-9322.

Falahatkar S, Mokhtari G, Moghaddam KG, Asadollahzade A, Farzan A, Shahab E, et al. Bipolar transurethral vaporization: a superior procedure in benign prostatic hyperplasia: a prospective randomized comparison with bipolar TURP. Int Braz J Urol. 2014 May-Jun;40(3):346-55.

Yang TK, Hsiao PJ, Yang HJ, Liao CH, Chiang HS, Chien KL. Body mass index and age are predictors for symptom improvement after high-power laser vaporization for benign prostatic hyperplasia. J Formos Med Assoc. 2015 Mar;114(3):268-73.

Sinanoglu O, Ekici S, Balci MC, Hazar AI, Nuhoglu B. Comparison of plasmakinetic transurethral resection of the prostate with monopolar transurethral resection of the prostate in terms of urethral stricture rates in patients with comorbidities. Prostate Int. 2014 Sep;2(3):121-6.

Sood R, Manasa T, Goel H, Singh RK, Singh R, Khattar N, Pandey P. Day care bipolar transurethral resection vs photoselective vaporisation under sedoanalgesia: A prospective, randomised study of the management of benign prostatic hyperplasia. Arab J Urol. 2017 Oct 12;15(4):331-338.

Müllhaupt G, Hechelhammer L, Diener PA, Engeler DS, Güsewell S, Schmid HP, Mordasini L, Abt D. Ejaculatory disorders after prostatic artery embolization: a reassessment of two prospective clinical trials. World J Urol. 2020 Oct;38(10):2595-2599.

Enikeev D, Glybochko P, Rapoport L, Potoldykova N, Sukhanov R, Enikeev M, et al. Impact of endoscopic enucleation of the prostate with thulium fiber laser on the erectile function. BMC Urol. 2018 Oct;18(1).

Sønksen J, Barber NJ, Speakman MJ, Berges R, Wetterauer U, Greene D, Sievert KD, et al. Prospective, randomized, multinational study of prostatic urethral lift versus transurethral resection of the prostate: 12-month results from the BPH6 study. Eur Urol. 2015 Oct;68(4):643-52.




DOI: http://dx.doi.org/10.29313/kedokteran.v7i1.26289

Flag Counter