Karakteristik Histopatologi Prostat dan Hasil Pemeriksan Laboratorium Glukosa, Ureum dan Kreatinin pada Pasien Pasca Operasi Benign Prostatic Hyperplasia di RS Al-Ihsan Tahun 2018-2019

Andry Julianto, Retno Ekowati, Heni Muflihah

Abstract


Abstract. BPH is enlarged prostate due to benign stromal proliferation and elements of the prostate gland. One of the factors that play a role in BPH proliferation is a metabolic syndrome which can be seen from laboratory tests such as glucose, urea, and creatinine, which can be supported by histopathological examination. This study aims to determine the histopathological characteristics of the prostate and the results of laboratory tests of glucose, urea and creatinine in BPH postoperative patients. Research conducted using a cross-sectional design. The study population was BPH patients at Al-Ihsan Regional Hospital Bandung. The sample consisted of 51 with a total sampling technique, the results of this study showed that the majority of patients were postoperative BPH. Based on histopathology, it is known that 36 people (70.6%) are BPH patients without comorbidities and the remaining 12 people (23.5%) are BPH patients with comorbidities. Most of the patient's sugar levels (92%) are normal. The patient's urge is more than half (59%) normal. Creatinine patients where more than half (69%) patients had abnormal creatinine. The conclusion is that in postoperative patients BPH the main characteristics are BPH without comorbidities, and glucose, urea levels in normal levels while creatinine levels are not normal

Keywords: Glucose, Ureum, Creatinine, Benign Prostatic Hyperplasia

Abstrak . BPH adalah pembesaran prostat akibat proliferasi stroma jinak dan elemen kelenjar prostat. Faktor yang berperan dalam proliferasi BPH salah satunya yaitu sindrom metabolik yang dapat dilihat dari pemeriksaan laboratorium seperti glukosa, ureum dan keratinin, yang dapat ditunjang dengan pemeriksaan histopatologi. Penelitian ini bertujuan untuk mengetahui karakteristik histopatologi prostat dan hasil pemeriksan laboratorium glukosa, ureum dan kreatinin pada pasien pasca operasi BPH. Penelitian yang dilakukan menggunakan desain cross sectional. Populasi penelitian ini adalah pasien BPH di RSUD Al-Ihsan Bandung. Sampel yang terdiri dari 51 dengan teknik total sampling, hasil penelitian ini menunjukkan bahwa sebagian besar pasien pasca operasi BPH. Berdasarkan histopatologi, diketahui bahwa 36 orang (70,6%) merupakan pasien BPH tanpa penyakit penyerta dan sisanya sebanyak 12 orang (23,5%) merupakan pasien BPH dengan penyakit penyerta. Kadar gula pasien sebagian besar (92%) normal. Ureum pasien lebih dari setengah (59%) normal. Kreatinin pasien dimana lebih dari setengah (69%) pasien memiliki kreatinin tidak normal. Kesimpulannya pada pasien pasca operasi BPH karakteristik utamanya adalah BPH tanpa penyakit penyerta, dan kadar glukosa, ureum dalam kadar normal sedangkan kadar kreatinin tidak normal.

Kata Kunci: Glukosa, Ureum, Kreatinin, Benign Prostatic Hyperplasia

 


Keywords


Glukosa, Ureum, Kreatinin, Benign Prostatic Hyperplasia

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References


Kumar. Robbins Basic Pathology, 9th ed. Elsevier. 2012.

WHO 2013. Globocan, 2013. Int Agency Res Cancer, World Heal Organ. 2013;

Kemalasari DW, Nilapsari R, Rusmartini T. Korelasi Disfungsi Seksual dengan Usia dan Terapi pada Benign Prostatic Hyperplasia. Glob Med Heal Commun. 2017; Glob Med Heal Commun. 2017;

Lim K Bin. Epidemiology of clinical benign prostatic hyperplasia. Asian J Urol [Internet]. 2017;4(3):148–51. Available from: http://dx.doi.org/10.1016/j.ajur.2017.06.004

Filzha A. Gambaran Benigna prostat Hiperplasia di RSUP Prof. Dr. R. D. Kandou MAnado Periode Januari-Juli 2017. 2016;4(September 2015):127–31.

Mochtar CA, Umbas R, Soebadi DM, Rasyid N, Noegroho BS, Poernomo BB, et al. Pedoman penatalaksanaan klinis pembesaran prostat jinak (benign prostatic hyperplasia / BPH). In 2015. p. 1–27.

Manuscript A. NIH Public Access. 2012;82:220–36.

Gerber GS, Goldfischer ER, Karrison TG, Bales GT. Serum creatinine measurements in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. Urology.

Loho IKA, Rambert GI, Wowor MF, Skripsi K, Kedokteran F, Sam U, et al. Gambaran kadar ureum pada pasien penyakit ginjal kronik stadium 5 non dialisis. 2016;4.

Moore KL, Dalley AF, Agur AMR. Clinically Oriented Anatomy (Seventh Edition). Lippincott Williams & Wilkins, a Wolters Kluwer business. 2014.

Mescher AL. Junqueira’s Basic Histology: Text and Atlas, Thirteenth Edition. McGraw-Hill Education. 2013.

Sherwood L. Fisiologi Manusia dari Sel ke Sistem. Fisiologi Manusia dari Sel ke Sistem. 2013.

Purnomo BB. Urology in Asia - Indonesia. Int J Urol. 2011;

Nash J. Benign prostatic hyperplasia: risk factors and management. Gerimed Midlife Beyond Urol. 2011;

Banerjee PP, Banerjee S, Brown TR, Zirkin BR. Androgen action in prostate function and disease. Am J Clin Exp Urol. 2018;

Sampson N, Madersbacher S, Berger P. Pathophysiology and therapy of benign prostatic hyperplasia. Wiener Klinische Wochenschrift. 2012.

McAninch JW, Lue TF. Smith & Tanagho’s General Urology. McGraw-Hill. 2013.

Roehrborn CG, McConnell J. Etiology, pathophysiology, epidemiology and natural history of benign prostatic hyperplasia. Campbell’s Urol. 2012;

W. Systemic inflammatory response in predicting prostate cancer: The diagnostic value of neutrophil-to-lymphocyte ratio. Int J Urol. 2017;

Cannon GW, Getzenberg RH. Biomarkers for benign prostatic hyperplasia progression. Curr Urol Rep. 2013;

Verdiansah. Pemeriksaan Fungsi Ginjal. J Diabetes. 2016;Vol.43 No.(2):148–54.

Denise D. Wilson. Manual of Laboratory and Diagnostic Test. McGraw-Hill. United States; 2011.

Biddulth. Pemilihan Modalitas Pemeriksaan Radiologi untuk Diagnosis Benign Prostatic Hyperplasia. 2016;43 no. 6(6):471. Available from: http://webcache.googleusercontent.com/search?q=cache:eEXBnbQQRNkJ:www.cdkjournal.com/index.php/CDK/article/download/75/72+&cd=1&hl=en&ct=clnk&gl=id&client=firefox-b-ab

Kaplan SA. Identification of the patient with enlarged prostate: Diagnosis and guidelines for management. Osteopath Med Prim Care. 2011;1:1–6.

Hasbullah B. Angka Kejadian Komplikasi Lambat Pascaoperasi Prostatektomi Transvesikal dan Reseksi Transuretral pada Pasien Pembesaran Prostat Jinak. Biomedika. 20;1(1):1–5.

Issa MM, Thwaites D. Transurethral resection of the prostate (TURP). Med Manag Surg Patient A Textb Perioper Med.;8:787–90.

Kim wt, Yun sj, Choi yd Kim gy Mon sk, Choi yh, Kim iy, Jae kw. Size Correlates with Fasting Blood Glucose in Non-Diabetic Benign Prostatic Hyperplasia Patients with Normal Testosterone Levels. 2011 Sep 1; (9): 1214-1218)

Edlin R.S, Heyns C.F, Van V.S.P, Zarrabi A.D. Prevalence of Histological Prostatistis In Men With Benign Prostatic Hyperplasia or Adenocarcinoma of The Prostate Presenting Without Urinary Retention. 2012 Nov 12;50(4): 127-30

Akdemir A.O, Oztekin C.V, Doluoglu O.G, Karabakan M, Ogulu O, Cetinkaya M. The Effect of Transuretral Resection of The Prostate on Morbidity and Mortality in Patient with Nondialysis-requiring Renal Insufficiency 2012 Apr;4(2):51-56




DOI: http://dx.doi.org/10.29313/kedokteran.v0i0.21565

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