Pengaruh Pemberian Etil Asetat Jahe Gajah terhadap Jumlah Islet of Langerhans Pankreaspada Mencit Metabolik Sindrom

Citra Aulia Shabaria, Wida Purbaningsih, Annisa Rahmah Furqaani

Abstract


Abstract. Breast cancer is a disease where the cells in the breast grow out of control. Breast cancer is the most common cancer in women, more than 1.5 million women get breast cancer each year, and cause the highest number of death because of cancer in women. Pathology anatomy examination is the gold standard for diagnosing cancer including knowing etiology to prognosis. This study aims to see the relationship between age and parity with histopathological features of breast tumors in Al-Ihsan Hospital. This study uses observational analytic methods. This study was obtained from secondary data in the form of medical records. Collection and processing of data are taken as a whole and meet the inclusion criteria. The results of the 64 respondents showed the age group> 40 years (85.9%), the highest histopathological type Invasive Ductal Carcinoma (92.2%), the most parity group was the multiparous group (81.3%) and the statistical test results showed that no there is a relationship between age and histopathology with a value of p = 0.544 (p <0.05) and the relationship between parity and histopathology with a value of p = 0.654 (p <0.05). Conclusion, there is no significant relationship between age and parity with histopathology of carcinoma in breast tumor patients in Al-Ihsan General Hospital 2015-2017.

Keywords: breast carcinoma, histopathology type, age, parity



Abstrak. Kanker payudara merupakan penyakit dimana sel-sel di payudara tumbuh tidak terkontrol. Kanker payudara adalah kanker yang paling sering terjadi pada wanita, lebih dari 1,5 juta wanita terkena kanker payudara setiap tahunnya, dan menyebabkan jumlah kematian akibat kanker terbanyak pada wanita. Pemeriksaan patologi anatomi merupakan standar baku untuk mendiagnosis kanker termasuk mengetahui etiologi sampai prognosis.penelitian ini bertujuan untuk melihat hubungan antara usia dan paritas dengan gambaran histopatologi pada tumor payudara di RSUD Al-Ihsan. Penelitian ini menggunakan metode analitik observasional. Penelitian ini diperoleh dari data sekunder berupa rekam medis. Pengumpuan dan pengolahan data diambil secara keseluruhan dan memenuhi kriteria inklusi. Hasil penelitian dari 64 responden menunjukan kelompok usia >40 tahun (85,9%), tipe histopatologi terbanyak Invasive Ductal Carcinoma (92,2%), kelompok paritas terbanyak adalah kelompok multipara (81,3%) dan hasil uji statistic menunjukan bahwa tidak terdapat hubungan antara usia dengan gambaran histopatologi dengan nilai p=0,544 (p<0,05) serta hubungan antara paritas dengan gambaran histopatologi dengan nilai p=0,654 (p<0,05). Kesimpulan, tidak terdapat huungan yang signifikan antara usia dan paritas dengan gambaran histopatologi karsinoma pada penderita tumor payudara di RSUD Al-Ihsan 2015-2017.

 

Kata kunci:  karsinoma payudara, Tipe histopatologi, Usia, Paritas


Keywords


Dislipidemia, jahe, pankreas, sindrom metabolik,

Full Text:

PDF

References


Grundy SM, Zimmet PZ, Cleemen JI, Donato KA. Harmonizing the metabolic syndrome. A joint interim statement on International Diabetes Federation, National Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, and International Association for The Study of Obesity. Circulation 2009;120:1640-5.

Kementerian Kesehatan. Gaya hidup Penyebab Kematian Kian Dominan. Kementeri Kesehat [Internet]. 2016;2015-7. Tersedia dari: http://pptm.depkes.go.id/cms/frontend/?p=infoslide&id=43

3. IDF IDF. The Metabolic, consensus worldwide definition of the Syndrome. Int Diabetes Fed. 2006;

4. Reaven GM, Alto P. Role of Insulin Resistance in Human Disease. 1988; Available from: http://diabetes.diabetesjournals.org/content/37/12/1595

5. Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract [Internet]. 2014;2014. Tersedia dari: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966331/

J. Fan , Y. Song , Y. Chen , R. Hui , W. Zhang . Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: a meta- analysis of prospective cohort studies. Int J Cardiol. 2013;168:4761-4768.

Elshater AA, Salman MMA, Moussa MMA. 2009. Effect of Ginger extract consumption on level of blood glucose, lipid profile and kidney functions in alloxan induce-diabetic rats. Egypt. Acad.J. biolog. Sci 2 (1) : 153-62

Perhimpunan Dokter Spesialis Kadiovaskular Indonesia (PERKI), Pedoman tatalaksana Dislipidemia Perhimpunan Dokter Spesialis Kardiovaskular Indonesia 2013

Ajijah, N., B. Martono., N. Bermawie dan E. A. Hadad.2013. Botani dan Karakteristik. Di dalam : Sitepu D., Sudiarto, N. Bermawie, Supriadi, D. Soetopo, Rosita S.M.D, Hernani, A.M. Rivai, editors. Monograf no 3 : Jahe. Balai Penelitian Tanaman Rempah dan Obat, Badan Litbang Deptan : 10-17.

Agoreyo FO, Agoreyo BO, Onuorah MN.2008. Effect of aqueous extracts ofHibiscus sabdariffa and Zingibarofficinale on blood cholesterol angglucose levels ofrats. African Journal ofBiotecnology Vol. 7 (21): 3949-51

Setyawan, A.D. Kekerabatan Berdasarkan Sifat-sifat Morfologi,Anatomi dan Kandungan Kimia Minyak Atsiri pada Anggota FamiliaZingiberaceae. Skripsi. Yogyakarta: Fakultas Biologi UGM.

Zheng T, Gao Y, Tian H. Relationship between blood lipid profles and pancreatic islet â cell function in Chinese men and women with normal glucose tolerance:across-sectional study. BMC Public Health. 2012;12:634

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, et al.

Relationships between lipid profles and metabolic syndrome, insulin resistance and serumhigh molecular adiponectin in Japanese community-dwelling adults. Lipids in Health and Disease 2011;10:79




DOI: http://dx.doi.org/10.29313/kedokteran.v0i0.15056

Flag Counter    Â