Hubungan Usia dan Paritas Dengan Gambaran Histopatologi Karsinoma pada Penderita Tumor Ganas Payudara
Abstract
Abstract. Breast cancer is a disease where the cells in the breast grow out of control. Breast cancer is the most common cancer in women, more than 1.5 million women get breast cancer each year, and cause the highest number of death because of cancer in women. Pathology anatomy examination is the gold standard for diagnosing cancer including knowing etiology to prognosis. This study aims to see the relationship between age and parity with histopathological features of breast tumors in Al-Ihsan Hospital. This study uses observational analytic methods. This study was obtained from secondary data in the form of medical records. Collection and processing of data are taken as a whole and meet the inclusion criteria. The results of the 64 respondents showed the age group> 40 years (85.9%), the highest histopathological type Invasive Ductal Carcinoma (92.2%), the most parity group was the multiparous group (81.3%) and the statistical test results showed that no there is a relationship between age and histopathology with a value of p = 0.544 (p <0.05) and the relationship between parity and histopathology with a value of p = 0.654 (p <0.05). Conclusion, there is no significant relationship between age and parity with histopathology of carcinoma in breast tumor patients in Al-Ihsan General Hospital 2015-2017.
Keywords: breast carcinoma, histopathology type, age, parityÂ
Abstrak. Kanker payudara merupakan penyakit dimana sel-sel di payudara tumbuh tidak terkontrol. Kanker payudara adalah kanker yang paling sering terjadi pada wanita, lebih dari 1,5 juta wanita terkena kanker payudara setiap tahunnya, dan menyebabkan jumlah kematian akibat kanker terbanyak pada wanita. Pemeriksaan patologi anatomi merupakan standar baku untuk mendiagnosis kanker termasuk mengetahui etiologi sampai prognosis.penelitian ini bertujuan untuk melihat hubungan antara usia dan paritas dengan gambaran histopatologi pada tumor payudara di RSUD Al-Ihsan. Penelitian ini menggunakan metode analitik observasional. Penelitian ini diperoleh dari data sekunder berupa rekam medis. Pengumpuan dan pengolahan data diambil secara keseluruhan dan memenuhi kriteria inklusi. Hasil penelitian dari 64 responden menunjukan kelompok usia >40 tahun (85,9%), tipe histopatologi terbanyak Invasive Ductal Carcinoma (92,2%), kelompok paritas terbanyak adalah kelompok multipara (81,3%) dan hasil uji statistic menunjukan bahwa tidak terdapat hubungan antara usia dengan gambaran histopatologi dengan nilai p=0,544 (p<0,05) serta hubungan antara paritas dengan gambaran histopatologi dengan nilai p=0,654 (p<0,05). Kesimpulan, tidak terdapat huungan yang signifikan antara usia dan paritas dengan gambaran histopatologi karsinoma pada penderita tumor payudara di RSUD Al-Ihsan 2015-2017.
Kata kunci: karsinoma payudara, Tipe histopatologi, Usia, Paritas
Keywords
Full Text:
PDFReferences
American Cancer Society. What is Breast Cancer? [homepage on the Internet]. Ameican Cancer Society Website. 2017 [diunduh 5 Januari 2018]. p. 1. Tersedia dari: https://www.cancer.org/cancer/breast-cancer/about/what-is-breast-cancer.html
World Health Organization | Breast cancer [homepage on the Internet]. WHO. World Health Organization; 2017 [diunduh 5 Januari 2018]. Tersedia dari: http://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/
Ghoncheh M, Mahdavifar N, Darvishi E, Salehiniya H. Epidemiology, Incidence and Mortality of Breast Cancer in Asia. Asian Pacific J Cancer Prev [Internet].2016;17(sup3):47–52. Available from: http://koreascience.or.kr/journal/view.jsp?kj=POCPA9&py=2016&vnc=v17nsup3&sp=47
Kementerian Kesehatan RI Pusat Data dan Informasi Kesehatan. Bulan Peduli Kanker Payudara. InfoDATIN. 2016. p. 2–6.
Vinay Kumar, Abul K. Abbas, Jon C. Aster JAP. Robbins basic pathology. 10th edition. Philadelphia, Pennsylvania; 2018.
Panigoro S, Hernowo BS, Purwanto H, Handojo, Haryono SJ, Arif W, et al. Panduan Penatalaksanaan Kanker Payudara. Kementeri Kesehat Republik Indones Kom Penanggulangan Kanker Nasional [Internet]. 2009;1, 12–4, 24–6, 45.
Leong ASY, Zhuang Z. The changing role of pathology in breast cancer diagnosis and treatment. Pathobiology. 2011;78(2):99–114.
Li CI, Uribe DJ, Daling JR. Clinical characteristics of different histologic types of breast cancer. Br J Cancer. 2005;93(9):1046–52.
Sulistiowati E, Haryono S, et al. Kadar c-erbb2 dalam serum dan saliva pasien kanker payudara. Pusat Teknologi Terapan Kesehatan dan Epidemiologi Klinik. 2014;42(4):223–30.
Reeves GK, Pirie K, Green J, Bull D, Beral V, Study W. Reproductive factors and specific histological types of breast cancer : prospective study and meta-analysis. 2009;(December 1999):538–44.
Rahmatya A, Khambri D, Mulyani H. Artikel Penelitian Hubungan Usia dengan Gambaran Klinikopatologi Kanker. J Kesehat Andalas. 2015;4(2):478–84.
Prabandari F. Pengaruh paritas dan riwayat penggunaan kb hormonal terhadap kejadian kanker payudara di rsu dadi keluarga purwokerto. :222–31.
Ray M Merrill. Reproductive epidemiology : principles and methods. 1st ed. Utah: Jones and Bartlett; 2010.
Breastcancer.Org. IDC — Invasive Ductal Carcinoma [homepage on the Internet]. Types of breast cancer. [diunduh 25 Januari 2018]. tersedia dari: http://www.breastcancer.org/symptoms/types/idc
Laelasari. Hubungan Usia dengan Tipe Histopatologi, Grading, dan Metastasis Kelenjar Getah Bening pada Penderita Karsinoma Payudara di Bagian Patologi Anatomi Rumah Sakit Al- Islam Bandung Periode 2012-2015.
Albrektsen G, Heuch I, Thoresen SØ. Histological type and grade of breast cancer tumors by parity , age at birth , and time since birth : a register-based study in Norway. 2010;
Butt S. Reproductive Factors and Breast Cancer - Parity , Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis. 2011;0–58.
DOI: http://dx.doi.org/10.29313/kedokteran.v0i0.15051
  Â