Pengaruh Pemberian Fraksi Air Jahe Gajah (Zingiber Officinale) terhadap Kadar Kolesterol Total dan Kadar Trigliserida pada Mencit Tua yang Diberi Pakan Tinggi Lemak

Firannisa Nanda Hardina Dwitami, Herri S. Sastramihardja, Miranti Kania Dewi

Abstract


Abstract. Dyslipidemia is condition of high level of Total Cholesterol and Triglyceride because of metabolic dysfunction. Ginger (Zingiber Officinale) is traditional spices that can be used for lowering Total Cholesterol levels and Triglyceride levels. Ginger contain Flavonoids molecule that can be used for lowering Cholesterol and Triglyceride by inhibits function of HMG-CoA reductation enzyme activity.The purpose of this study was to analyze the effect of water fractination from ginger on Total Cholesterol and Triglyceride levels on an old male mice that fed by high fat food. Laboratory experimental research used old male mice (45-49 weeks) that are divided into 5 groups. Group I was given ginger fraction 19,9 mg/20grBW/Day, Group II was given ginger fraction 39,8 mg/20grBW/Day, Group III was given ginger fraction 79,6 mg/20grBW/Day, positive control group was given standard food and fraction solvent , and negative control group was given high fat food and fraction solvent. This study using analysis of one way annova. The mean Total cholesterol rate after study was: 133 mg/dL; 111 mg/dL; 103 mg/dL; 118,67 mg/dL; 130,5 mg/dL. The mean Triglyceride rate after study was: 116 mg/dL; 113 mg/dL; 108 mg/dL; 147,33 mg/dL; 205,5 mg/dL. Measurement of Total Cholesterol was related but not significance (p>0,05) Measurement of Triglyceride was related and significance (p<0,05) between group that treated and the control. The result of this study shows that there was an effect from ginger for lowering Total Cholesterol and Triglyceride levels with fraction 79,6 mg/20grBW/Day .

Keywords: dyslipidemia, ginger fraction, total cholesterol, triglyceride

Abstrak. Dislipidemia merupakan kelainan metabolisme lipid yang diataranya ditandai dengan peningkatan kadar koletrol dan trigliserida. Salah satu bahan tradisional yang digunakan untuk menekan peningkatan kadar kolesterol total dan trigliserida adalah tanaman jahe gajah (Zingiber Officinale). Jahe gajah memiliki kandungan aktif berupa flavonoid yang bersifat antioksidan yang diketahui dapat menekan enzim HMG-KoA reduktase sehingga dapat menghambat peningkatan kadar kolrdterol total dan trigliserida. Penelitian ini bertujuan untuk mengetahui pengaruh fraksi air jahe gajah terhadap kadar kolesterol total dan trigliserida pada mencit yang diberikan pakan tinggi lemak. Penelitian ini bersifat eksperimental menggunakan mencit jantan tua (45-49 mingggu) yang terbagi menjadi 5 kelompok. Kelompok perlakuan I diberikan fraksi air jahe gajah 8 gram/kgBB/Hari, kelompok perlakuan II diberikan fraksi air jahe gajah 16 gram/kgBB/Hari, kelompok perlakuan III diberikan fraksi air jahe gajah 79,9 32 gram/kgBB/Hari, kontrol positif diberikan pakan standard dan pelarut fraksi, dan kelompok kontrol negatif yang diberikan pakan tinggi lemak dan pelarut fraksi. Analisis statistika pada penelitian ini dilakukan menggunakan uji one way annova. Hasil rerata kadar kolesterol total setelah perlakuan adalah: 133 mg/dL; 111 mg/dL; 103 mg/dL; 118,67 mg/dL; 130,5 mg/dL. Hasil rerata kadar trigliserida setelah perlakuan adalah: 116 mg/dL; 113 mg/dL; 108 mg/dL; 147,33 mg/dL; 205,5 mg/dL. Pengkuran kolesterol total bermakna tidak signifikan (p>0,005) dan pada pengkukuran kadar trigliserida bermakna signifikan (p<0,05) antara kelompok perlakuan dan kelompok kontrol. Hasil penelitian ini menunjukan adanya pengaruh pemberian fraksi air jahe gajah terhadap kadar kolesterol total dan trigliserida.

 

Kata kunci: dislipidemia, fraksi jahe gajah, koleterol total, trigliserida


Keywords


dislipidemia, fraksi jahe gajah, koleterol total, trigliserida

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DOI: http://dx.doi.org/10.29313/kedokteran.v0i0.14694

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